Expression of UGCG in cancer - Summary - The Human Protein Atlas

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UGCG

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UGCG
Gene description	UDP-glucose ceramide glucosyltransferase
Protein class	Enzymes FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA024124
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and cervical cancer (favourable).
Endometrial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024124

GENE INFORMATION
Gene name	UGCG (HGNC Symbol)
Synonyms	GCS
Description	UDP-glucose ceramide glucosyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]
Chromosome	9
Cytoband	q31.3
Chromosome location (bp)	111896766 - 111935369
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148154 (version 83.38)
Entrez gene	7357
UniProt	Q16739 (UniProt - Evidence at protein level)
neXtProt	NX_Q16739
Antibodypedia	UGCG antibodies

PROTEIN BROWSER

UGCG-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UGCG-001 ENSP00000363397 ENST00000374279	Q16739 [Direct mapping] Ceramide glucosyltransferase A0A024R157 [Target identity:100%; Query identity:100%] UDP-glucose ceramide glucosyltransferase, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006665 [sphingolipid metabolic process] GO:0006679 [glucosylceramide biosynthetic process] GO:0006687 [glycosphingolipid metabolic process] GO:0006688 [glycosphingolipid biosynthetic process] GO:0008120 [ceramide glucosyltransferase activity] GO:0008544 [epidermis development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0044281 [small molecule metabolic process] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	394 aa 44.9 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.