Expression of ACTL7B in cancer - Summary - The Human Protein Atlas

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ACTL7B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACTL7B
Gene description	Actin-like 7B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective nuclear and cytoplasmic expression in spermatids of seminiferus ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA021803 , HPA024664
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021803	HPA024664

GENE INFORMATION
Gene name	ACTL7B (HGNC Symbol)
Synonyms	Tact1
Description	Actin-like 7B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q31.3
Chromosome location (bp)	108854589 - 108856967
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148156 (version 83.38)
Entrez gene	10880
UniProt	Q9Y614 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y614
Antibodypedia	ACTL7B antibodies

PROTEIN BROWSER

ACTL7B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTL7B-001 ENSP00000363799 ENST00000374667	Q9Y614 [Direct mapping] Actin-like protein 7B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005737 [cytoplasm] GO:0015629 [actin cytoskeleton] Show all	415 aa 45.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.