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GSN

GENERAL INFORMATION

Gene name

 GSN

Gene description

 Gelsolin

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HaCaT)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in macrophages in several tissues, and in renal glomeruli, glial cells and in islets of Langerhans.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA054026 , CAB010823 , CAB016728 , CAB036009
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054026
CAB010823
CAB016728
CAB036009

GENE INFORMATION

Gene name

 GSN (HGNC Symbol)

Synonyms

 DKFZp313L0718

Description

 Gelsolin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene binds to the ""plus"" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q33.2

Chromosome location (bp)

 121207794 - 121332843

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148180 (version 83.38)

Entrez gene

 2934

UniProt

 P06396 (UniProt - Evidence at protein level)

neXtProt

 NX_P06396

Antibodypedia

 GSN antibodies

PROTEIN BROWSER
«
GSN-001
GSN-002
GSN-003
GSN-006
GSN-013
GSN-015
GSN-016
GSN-201
GSN-202
GSN-203
GSN-204
GSN-205
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GSN-001
ENSP00000362924
ENST00000373818
P06396 [Direct mapping]
Gelsolin
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007568 [aging]
GO:0008154 [actin polymerization or depolymerization]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0014003 [oligodendrocyte development]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016192 [vesicle-mediated transport]
GO:0016528 [sarcoplasm]
GO:0019904 [protein domain specific binding]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030155 [regulation of cell adhesion]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0042060 [wound healing]
GO:0042246 [tissue regeneration]
GO:0042989 [sequestering of actin monomers]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0045471 [response to ethanol]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051593 [response to folic acid]
GO:0051693 [actin filament capping]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071276 [cellular response to cadmium ion]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903689 [regulation of wound healing, spreading of epidermal cells]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 782 aa
85.7 kDa 		Yes 0
GSN-002
ENSP00000404226
ENST00000432226
Q5T0I0 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
Show all
 260 aa
29 kDa 		No 0
GSN-003
ENSP00000410657
ENST00000449773
Q5T0I1 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
Show all
 228 aa
25.9 kDa 		No 0
GSN-006
ENSP00000489067
ENST00000477104
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
Show all
 232 aa
26.3 kDa 		No 0
GSN-013
ENSP00000362929
ENST00000373823
P06396 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0019904 [protein domain specific binding]
GO:0030041 [actin filament polymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0042989 [sequestering of actin monomers]
GO:0044267 [cellular protein metabolic process]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903689 [regulation of wound healing, spreading of epidermal cells]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 731 aa
80.6 kDa 		No 0
GSN-015
ENSP00000377882
ENST00000394353
A0A0A0MS51 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
Show all
 748 aa
82.5 kDa 		No 0
GSN-016
ENSP00000445823
ENST00000545652
P06396 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0019904 [protein domain specific binding]
GO:0030041 [actin filament polymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0042989 [sequestering of actin monomers]
GO:0044267 [cellular protein metabolic process]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903689 [regulation of wound healing, spreading of epidermal cells]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 739 aa
81.5 kDa 		No 0
GSN-201
ENSP00000340888
ENST00000341272
P06396 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0019904 [protein domain specific binding]
GO:0030041 [actin filament polymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0042989 [sequestering of actin monomers]
GO:0044267 [cellular protein metabolic process]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903689 [regulation of wound healing, spreading of epidermal cells]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 731 aa
80.6 kDa 		No 0
GSN-202
ENSP00000362914
ENST00000373808
P06396 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0019904 [protein domain specific binding]
GO:0030041 [actin filament polymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0042989 [sequestering of actin monomers]
GO:0044267 [cellular protein metabolic process]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903689 [regulation of wound healing, spreading of epidermal cells]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 731 aa
80.6 kDa 		No 0
GSN-203
ENSP00000416586
ENST00000412819
P06396 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0019904 [protein domain specific binding]
GO:0030041 [actin filament polymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0042989 [sequestering of actin monomers]
GO:0044267 [cellular protein metabolic process]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903689 [regulation of wound healing, spreading of epidermal cells]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 731 aa
80.6 kDa 		No 0
GSN-204
ENSP00000411293
ENST00000436847
P06396 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006911 [phagocytosis, engulfment]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0014891 [striated muscle atrophy]
GO:0015629 [actin cytoskeleton]
GO:0016528 [sarcoplasm]
GO:0019904 [protein domain specific binding]
GO:0030041 [actin filament polymerization]
GO:0030478 [actin cap]
GO:0030864 [cortical actin cytoskeleton]
GO:0031648 [protein destabilization]
GO:0042989 [sequestering of actin monomers]
GO:0044267 [cellular protein metabolic process]
GO:0045010 [actin nucleation]
GO:0045159 [myosin II binding]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
GO:0051127 [positive regulation of actin nucleation]
GO:0051693 [actin filament capping]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071801 [regulation of podosome assembly]
GO:0072562 [blood microparticle]
GO:0090527 [actin filament reorganization]
GO:0097017 [renal protein absorption]
GO:0097284 [hepatocyte apoptotic process]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:1903689 [regulation of wound healing, spreading of epidermal cells]
GO:1903903 [regulation of establishment of T cell polarity]
GO:1903906 [regulation of plasma membrane raft polarization]
GO:1903909 [regulation of receptor clustering]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
GO:1990000 [amyloid fibril formation]
GO:2001269 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 742 aa
81.9 kDa 		No 0
GSN-205
ENSP00000409358
ENST00000449733
A0A0A0MT01 [Direct mapping]
Gelsolin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0045010 [actin nucleation]
GO:0051014 [actin filament severing]
GO:0051016 [barbed-end actin filament capping]
Show all
 767 aa
84.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.