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NR6A1

GENERAL INFORMATION

Gene name

 NR6A1

Gene description

 Nuclear receptor subfamily 6, group A, member 1

Protein class

 Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enhanced (BEWO, K-562, NTERA-2)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 NR6A1 (HGNC Symbol)

Synonyms

 CT150, GCNF, GCNF1, RTR

Description

 Nuclear receptor subfamily 6, group A, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

Chromosome

 9

Cytoband

 q33.3

Chromosome location (bp)

 124517275 - 124771310

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148200 (version 83.38)

Entrez gene

 2649

UniProt

 Q15406 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15406

Antibodypedia

 NR6A1 antibodies

PROTEIN BROWSER
NR6A1-001
NR6A1-002
NR6A1-003
NR6A1-004
NR6A1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR6A1-001
ENSP00000420267
ENST00000487099
Q15406 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1
F1D8S0 [Target identity:100%; Query identity:100%]
Germ cell nuclear factor variant 1; Nuclear receptor subfamily 6, group A, member 1, isoform CRA_b
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007276 [gamete generation]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 480 aa
54.4 kDa 		No 0
NR6A1-002
ENSP00000413701
ENST00000416460
Q15406 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007276 [gamete generation]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 475 aa
53.9 kDa 		No 0
NR6A1-003
ENSP00000362686
ENST00000373584
Q15406 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1
F1DAM1 [Target identity:100%; Query identity:100%]
Germ cell nuclear factor; Nuclear receptor subfamily 6, group A, member 1, isoform CRA_a
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007276 [gamete generation]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 476 aa
54 kDa 		No 0
NR6A1-004
ENSP00000341135
ENST00000344523
Q15406 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007276 [gamete generation]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 479 aa
54.3 kDa 		No 0
NR6A1-005
ENSP00000420587
ENST00000475178
C9JDI9 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1
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Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 233 aa
26.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.