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POLE3

GENERAL INFORMATION

Gene name

 POLE3

Gene description

 Polymerase (DNA directed), epsilon 3, accessory subunit

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA047945
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047945

GENE INFORMATION

Gene name

 POLE3 (HGNC Symbol)

Synonyms

 CHARAC17, CHRAC17, p17, Ybl1

Description

 Polymerase (DNA directed), epsilon 3, accessory subunit (HGNC Symbol)

Entrez gene summary

 POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

Chromosome

 9

Cytoband

 q32

Chromosome location (bp)

 113407235 - 113410672

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148229 (version 83.38)

Entrez gene

 54107

UniProt

 Q9NRF9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRF9

Antibodypedia

 POLE3 antibodies

PROTEIN BROWSER
POLE3-003
POLE3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLE3-003
ENSP00000363284
ENST00000374169
Q9NRF9 [Direct mapping]
DNA polymerase epsilon subunit 3
A0A024R829 [Target identity:100%; Query identity:100%]
Polymerase (DNA directed), epsilon 3 (P17 subunit), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0006260 [DNA replication]
GO:0008622 [epsilon DNA polymerase complex]
GO:0043966 [histone H3 acetylation]
GO:0046982 [protein heterodimerization activity]
GO:0071897 [DNA biosynthetic process]
Show all
 147 aa
16.9 kDa 		No 0
POLE3-004
ENSP00000363286
ENST00000374171
Q9NRF9 [Direct mapping]
DNA polymerase epsilon subunit 3
A0A024R829 [Target identity:100%; Query identity:100%]
Polymerase (DNA directed), epsilon 3 (P17 subunit), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0006260 [DNA replication]
GO:0008622 [epsilon DNA polymerase complex]
GO:0043966 [histone H3 acetylation]
GO:0046982 [protein heterodimerization activity]
GO:0071897 [DNA biosynthetic process]
Show all
 147 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.