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Several cases of malignant glioma, malignant melanoma, prostate, ovarian, cervical, endometrial, renal, pancreatic and liver cancer displayed moderate to strong cytoplasmic staining with nuclear positivity in a few cases. Remaining malignant tissues were weakly stained or negative.
This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]