Expression of ASB6 in cancer - Summary - The Human Protein Atlas

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ASB6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASB6
Gene description	Ankyrin repeat and SOCS box containing 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA004341
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and liver cancer (unfavourable).
Colorectal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004341

GENE INFORMATION
Gene name	ASB6
Synonyms
Description	Ankyrin repeat and SOCS box containing 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	129634604 - 129642169
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148331 (version 83.38)
Entrez gene	140459
UniProt	Q9NWX5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWX5
Antibodypedia	ASB6 antibodies

PROTEIN BROWSER

ASB6-001	ASB6-002	ASB6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASB6-001 ENSP00000277458 ENST00000277458	Q9NWX5 [Direct mapping] Ankyrin repeat and SOCS box protein 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	421 aa 47.1 kDa	No	0
ASB6-002 ENSP00000277459 ENST00000277459	Q9NWX5 [Direct mapping] Ankyrin repeat and SOCS box protein 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	197 aa 22.4 kDa	No	0
ASB6-201 ENSP00000416172 ENST00000450050	F6TX30 [Direct mapping] Ankyrin repeat and SOCS box protein 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	392 aa 44.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.