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C9orf142

GENERAL INFORMATION

Gene name

 C9orf142

Gene description

 Chromosome 9 open reading frame 142

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA045268
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and pancreatic cancer (favourable).
Cervical cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045268

GENE INFORMATION

Gene name

 C9orf142 (HGNC Symbol)

Synonyms

 PAXX

Description

 Chromosome 9 open reading frame 142 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 136992418 - 136993984

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148362 (version 83.38)

Entrez gene

 286257

UniProt

 Q9BUH6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUH6

Antibodypedia

 C9orf142 antibodies

PROTEIN BROWSER
C9orf142-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C9orf142-004
ENSP00000360682
ENST00000371620
Q9BUH6 [Direct mapping]
Protein PAXX
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0042803 [protein homodimerization activity]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070062 [extracellular exosome]
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 204 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.