Expression of COMMD3 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

COMMD3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COMMD3
Gene description	COMM domain containing 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA036584
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036584

GENE INFORMATION
Gene name	COMMD3 (HGNC Symbol)
Synonyms	BUP, C10orf8
Description	COMM domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	p12.2
Chromosome location (bp)	22315974 - 22320308
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148444 (version 83.38)
Entrez gene	23412
UniProt	Q9UBI1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBI1
Antibodypedia	COMMD3 antibodies

PROTEIN BROWSER

COMMD3-001	COMMD3-002	COMMD3-003	COMMD3-004	COMMD3-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COMMD3-001 ENSP00000366032 ENST00000376836	Q9UBI1 [Direct mapping] COMM domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006814 [sodium ion transport] Show all	195 aa 22.2 kDa	No	0
COMMD3-002 ENSP00000394580 ENST00000456711	H0Y4W0 [Direct mapping] COMM domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18.2 kDa	No	0
COMMD3-003 ENSP00000408982 ENST00000444869	H0Y6Z9 [Direct mapping] COMM domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		177 aa 20.2 kDa	No	0
COMMD3-004 ENSP00000391237 ENST00000448361	H0Y4E5 [Direct mapping] COMM domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.6 kDa	No	0
COMMD3-017 ENSP00000473624 ENST00000471350	R4GNF2 [Direct mapping] COMM domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.