Expression of FAM171A1 in cancer - Summary

GENERAL INFORMATION
Gene name	FAM171A1
Gene description	Family with sequence similarity 171, member A1
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, some tissues with additional nuclear or membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051345
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable) and renal cancer (favourable).
Thyroid cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA051345

GENE INFORMATION
Gene name	FAM171A1 (HGNC Symbol)
Synonyms	C10orf38, FLJ12884
Description	Family with sequence similarity 171, member A1 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	p13
Chromosome location (bp)	15211643 - 15371062
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148468 (version 83.38)
Entrez gene	221061
UniProt	Q5VUB5 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VUB5
Antibodypedia	FAM171A1 antibodies

PROTEIN BROWSER

FAM171A1-001	FAM171A1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM171A1-001 ENSP00000367356 ENST00000378116	Q5VUB5 [Direct mapping] Protein FAM171A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	890 aa 97.9 kDa	Yes	1
FAM171A1-002 ENSP00000407796 ENST00000455654	Q5SW12 [Direct mapping] Protein FAM171A1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 21.3 kDa	Yes	0