Fields »
ABOUT
HELP
BLOG
PARD3

GENERAL INFORMATION

Gene name

 PARD3

Gene description

 Par-3 family cell polarity regulator

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression mainly in squamous and glandular epithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA030443
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and urothelial cancer (unfavourable).
Liver cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030443

GENE INFORMATION

Gene name

 PARD3 (HGNC Symbol)

Synonyms

 ASIP, Baz, Bazooka, PAR3, PARD3A, PPP1R118

Description

 Par-3 family cell polarity regulator (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 10

Cytoband

Chromosome location (bp)

 34109560 - 34815325

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148498 (version 83.38)

Entrez gene

 56288

UniProt

 Q8TEW0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TEW0

Antibodypedia

 PARD3 antibodies

PROTEIN BROWSER
«
PARD3-001
PARD3-002
PARD3-003
PARD3-004
PARD3-005
PARD3-006
PARD3-007
PARD3-009
PARD3-010
PARD3-201
PARD3-202
PARD3-203
PARD3-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PARD3-001
ENSP00000363908
ENST00000374776
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 988 aa
108.5 kDa 		No 0
PARD3-002
ENSP00000363921
ENST00000374789
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0003383 [apical constriction]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005913 [cell-cell adherens junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0019903 [protein phosphatase binding]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0032970 [regulation of actin filament-based process]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0044295 [axonal growth cone]
GO:0044319 [wound healing, spreading of cells]
GO:0045177 [apical part of cell]
GO:0045216 [cell-cell junction organization]
GO:0051642 [centrosome localization]
GO:0060341 [regulation of cellular localization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 1356 aa
151.4 kDa 		No 0
PARD3-003
ENSP00000363920
ENST00000374788
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 1353 aa
151.1 kDa 		No 0
PARD3-004
ENSP00000340591
ENST00000346874
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 1319 aa
146.9 kDa 		No 0
PARD3-005
ENSP00000363926
ENST00000374794
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 1244 aa
138.3 kDa 		No 0
PARD3-006
ENSP00000311986
ENST00000350537
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 1310 aa
146.3 kDa 		No 0
PARD3-007
ENSP00000363900
ENST00000374768
B1AP52 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 179 aa
19.3 kDa 		No 0
PARD3-009
ENSP00000363905
ENST00000374773
Q5VWU8 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1001 aa
110 kDa 		No 0
PARD3-010
ENSP00000363922
ENST00000374790
Q5VWV2 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030054 [cell junction]
Show all
 1296 aa
144.5 kDa 		No 0
PARD3-201
ENSP00000341844
ENST00000340077
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 1031 aa
113.4 kDa 		No 0
PARD3-202
ENSP00000444429
ENST00000544292
F5GZI3 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 747 aa
82.1 kDa 		No 0
PARD3-203
ENSP00000440857
ENST00000545260
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 1266 aa
141.1 kDa 		No 0
PARD3-204
ENSP00000443147
ENST00000545693
Q8TEW0 [Direct mapping]
Partitioning defective 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006612 [protein targeting to membrane]
GO:0007049 [cell cycle]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008356 [asymmetric cell division]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0012505 [endomembrane system]
GO:0022011 [myelination in peripheral nervous system]
GO:0030054 [cell junction]
GO:0031643 [positive regulation of myelination]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0033269 [internode region of axon]
GO:0034329 [cell junction assembly]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
GO:0090162 [establishment of epithelial cell polarity]
Show all
 1340 aa
149.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.