Tissue expression of RGR - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RGR
Gene description	Retinal G protein coupled receptor
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, testis)
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	RGR (HGNC Symbol)
Synonyms	RP44
Description	Retinal G protein coupled receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q23.1
Chromosome location (bp)	84245053 - 84259960
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148604 (version 83.38)
Entrez gene	5995
UniProt	P47804 (UniProt - Evidence at protein level)
neXtProt	NX_P47804
Antibodypedia	RGR antibodies

PROTEIN BROWSER

RGR-001	RGR-002	RGR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RGR-001 ENSP00000352427 ENST00000359452	P47804 [Direct mapping] RPE-retinal G protein-coupled receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Opsins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0009881 [photoreceptor activity] GO:0016021 [integral component of membrane] GO:0018298 [protein-chromophore linkage] Show all	295 aa 32.4 kDa	No	7
RGR-002 ENSP00000361164 ENST00000372092	Q96HT6 [Direct mapping] RGR protein; RPE-retinal G protein-coupled receptor; Retinal G protein coupled receptor, isoform CRA_b Show all	Predicted intracellular proteins Show all		120 aa 12.8 kDa	No	0
RGR-201 ENSP00000350823 ENST00000358110	P47804 [Direct mapping] RPE-retinal G protein-coupled receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Opsins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0009881 [photoreceptor activity] GO:0016021 [integral component of membrane] GO:0018298 [protein-chromophore linkage] Show all	253 aa 27.7 kDa	No	5