Tissue expression of POLR3A - Summary - The Human Protein Atlas

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POLR3A

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	POLR3A
Gene description	Polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins RNA polymerase related proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA037926
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	POLR3A (HGNC Symbol)
Synonyms	hRPC155, RPC1, RPC155
Description	Polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
Chromosome	10
Cytoband	q22.3
Chromosome location (bp)	77969251 - 78029545
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148606 (version 83.38)
Entrez gene	11128
UniProt	O14802 (UniProt - Evidence at protein level)
neXtProt	NX_O14802
Antibodypedia	POLR3A antibodies

PROTEIN BROWSER

POLR3A-002	POLR3A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR3A-002 ENSP00000361446 ENST00000372371	O14802 [Direct mapping] DNA-directed RNA polymerase III subunit RPC1 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins RNA polymerase related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005654 [nucleoplasm] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0032481 [positive regulation of type I interferon production] GO:0032728 [positive regulation of interferon-beta production] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0051607 [defense response to virus] GO:1903146 [regulation of mitophagy] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	1390 aa 155.6 kDa	No	0
POLR3A-201 ENSP00000483738 ENST00000616246	Q7Z755 [Direct mapping] DNA-directed RNA polymerase III subunit RPC1; POLR3A protein Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0006351 [transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] Show all	162 aa 18.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.