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ADD3

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GENERAL INFORMATION

Gene name

 ADD3

Gene description

 Adducin 3 (gamma)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Cell line enhanced (ASC TERT1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA035696
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035696 HEK 293 Plasma membrane
HPA035696 U-2 OS Nucleoplasm
Plasma membrane

GENE INFORMATION

Gene name

 ADD3 (HGNC Symbol)

Synonyms

 ADDL

Description

 Adducin 3 (gamma) (HGNC Symbol)

Entrez gene summary

 Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

Chromosome location (bp)

 109996368 - 110135565

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148700 (version 83.38)

Entrez gene

 120

UniProt

 Q9UEY8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UEY8

Antibodypedia

 ADD3 antibodies

PROTEIN BROWSER
ADD3-001
ADD3-002
ADD3-003
ADD3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADD3-001
ENSP00000348381
ENST00000356080
Q9UEY8 [Direct mapping]
Gamma-adducin
Q5VU08 [Target identity:100%; Query identity:100%]
Adducin 3 (Gamma), isoform CRA_a; cDNA FLJ77558, highly similar to Homo sapiens adducin 3 (gamma) (ADD3), transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000794 [condensed nuclear chromosome]
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005938 [cell cortex]
GO:0016020 [membrane]
GO:0042493 [response to drug]
GO:0055085 [transmembrane transport]
GO:0097481 [neuronal postsynaptic density]
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 706 aa
79.2 kDa 		No 0
ADD3-002
ENSP00000277900
ENST00000277900
Q9UEY8 [Direct mapping]
Gamma-adducin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005516 [calmodulin binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0055085 [transmembrane transport]
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 674 aa
75.7 kDa 		No 0
ADD3-003
ENSP00000353286
ENST00000360162
Q9UEY8 [Direct mapping]
Gamma-adducin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005516 [calmodulin binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0055085 [transmembrane transport]
Show all
 674 aa
75.7 kDa 		No 0
ADD3-201
ENSP00000480646
ENST00000611329
A0A087WX08 [Direct mapping]
Gamma-adducin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
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 672 aa
75.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.