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MTG1

GENERAL INFORMATION

Gene name

 MTG1

Gene description

 Mitochondrial ribosome-associated GTPase 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA037826 , HPA037827
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA037826
HPA037827

GENE INFORMATION

Gene name

 MTG1 (HGNC Symbol)

Synonyms

 GTPBP7

Description

 Mitochondrial ribosome-associated GTPase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q26.3

Chromosome location (bp)

 133394094 - 133421307

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148824 (version 83.38)

Entrez gene

 92170

UniProt

 Q9BT17 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BT17

Antibodypedia

 MTG1 antibodies

PROTEIN BROWSER
MTG1-001
MTG1-005
MTG1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTG1-001
ENSP00000323047
ENST00000317502
Q9BT17 [Direct mapping]
Mitochondrial ribosome-associated GTPase 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005761 [mitochondrial ribosome]
GO:0042254 [ribosome biogenesis]
GO:0044065 [regulation of respiratory system process]
GO:0070129 [regulation of mitochondrial translation]
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 334 aa
37.2 kDa 		No 0
MTG1-005
ENSP00000475596
ENST00000477902
U3KQ69 [Direct mapping]
Mitochondrial GTPase 1
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Predicted intracellular proteins
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GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005739 [mitochondrion]
GO:0042254 [ribosome biogenesis]
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 293 aa
32.6 kDa 		No 0
MTG1-006
ENSP00000393480
ENST00000432508
E7EVK2 [Direct mapping]
Mitochondrial ribosome-associated GTPase 1
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Predicted intracellular proteins
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GO:0003924 [GTPase activity]
GO:0005739 [mitochondrion]
GO:0042254 [ribosome biogenesis]
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 283 aa
31.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.