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TAF5

GENERAL INFORMATION

Gene name

 TAF5

Gene description

 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006195 , HPA006474
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and stomach cancer (favourable).
Renal cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA006195
HPA006474

GENE INFORMATION

Gene name

 TAF5 (HGNC Symbol)

Synonyms

 TAF2D, TAFII100

Description

 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa (HGNC Symbol)

Entrez gene summary

 Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.33

Chromosome location (bp)

 103367967 - 103389065

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148835 (version 83.38)

Entrez gene

 6877

UniProt

 Q15542 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15542

Antibodypedia

 TAF5 antibodies

PROTEIN BROWSER
TAF5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF5-001
ENSP00000358854
ENST00000369839
Q15542 [Direct mapping]
Transcription initiation factor TFIID subunit 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0016032 [viral process]
GO:0016568 [chromatin modification]
GO:0016573 [histone acetylation]
GO:0033276 [transcription factor TFTC complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046983 [protein dimerization activity]
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 800 aa
86.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.