Expression of CNNM2 in cancer - Summary - The Human Protein Atlas

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CNNM2

TISSUE

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CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CNNM2
Gene description	Cyclin and CBS domain divalent metal cation transport mediator 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CNNM2 (HGNC Symbol)
Synonyms	ACDP2
Description	Cyclin and CBS domain divalent metal cation transport mediator 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	10
Cytoband	q24.32
Chromosome location (bp)	102918293 - 103090221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148842 (version 83.38)
Entrez gene	54805
UniProt	Q9H8M5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H8M5
Antibodypedia	CNNM2 antibodies

PROTEIN BROWSER

CNNM2-001	CNNM2-002	CNNM2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNNM2-001 ENSP00000358894 ENST00000369878	Q9H8M5 [Direct mapping] Metal transporter CNNM2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0010960 [magnesium ion homeostasis] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] Show all	875 aa 96.6 kDa	No	5
CNNM2-002 ENSP00000392875 ENST00000433628	Q9H8M5 [Direct mapping] Metal transporter CNNM2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0010960 [magnesium ion homeostasis] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] Show all	853 aa 94.3 kDa	No	5
CNNM2-004 ENSP00000358891 ENST00000369875	Q9H8M5 [Direct mapping] Metal transporter CNNM2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0010960 [magnesium ion homeostasis] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] Show all	552 aa 60.5 kDa	No	5

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.