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PDCD11

GENERAL INFORMATION

Gene name

 PDCD11

Gene description

 Programmed cell death 11

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nucleolar and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA017924 , CAB026472
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017924
CAB026472

GENE INFORMATION

Gene name

 PDCD11 (HGNC Symbol)

Synonyms

 ALG-4, KIAA0185, RRP5

Description

 Programmed cell death 11 (HGNC Symbol)

Entrez gene summary

 PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]

Chromosome

 10

Cytoband

 q24.33

Chromosome location (bp)

 103396648 - 103446292

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148843 (version 83.38)

Entrez gene

 22984

UniProt

 Q14690 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14690

Antibodypedia

 PDCD11 antibodies

PROTEIN BROWSER
PDCD11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDCD11-001
ENSP00000358812
ENST00000369797
Q14690 [Direct mapping]
Protein RRP5 homolog
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008134 [transcription factor binding]
GO:0032040 [small-subunit processome]
GO:0044822 [poly(A) RNA binding]
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 1871 aa
208.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.