Expression of ADAM12 in cancer - Summary - The Human Protein Atlas

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ADAM12

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAM12
Gene description	ADAM metallopeptidase domain 12
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (U-2197, U-251 MG, U-87 MG)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in placental trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA030866 , HPA030867 , HPA030868
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030866	HPA030867	HPA030868

GENE INFORMATION
Gene name	ADAM12 (HGNC Symbol)
Synonyms	MCMPMltna, MLTN
Description	ADAM metallopeptidase domain 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	126012381 - 126388455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148848 (version 83.38)
Entrez gene	8038
UniProt	O43184 (UniProt - Evidence at protein level)
neXtProt	NX_O43184
Antibodypedia	ADAM12 antibodies

PROTEIN BROWSER

ADAM12-001	ADAM12-002	ADAM12-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM12-001 ENSP00000357668 ENST00000368679	O43184 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 12 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007520 [myoblast fusion] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] Show all	909 aa 99.5 kDa	Yes	1
ADAM12-002 ENSP00000357665 ENST00000368676	O43184 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 12 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007520 [myoblast fusion] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] Show all	738 aa 80.4 kDa	Yes	0
ADAM12-003 ENSP00000391268 ENST00000448723	Q5JRP2 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 12 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	278 aa 31.1 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.