A majority of gastric cancers as well as several colorectal and urothelial cancers showed moderate to strong positivity. Most endometrial cancers and cases of several other cancers including prostate and renal cancers were moderately stained. Cancer tissues were in general negative.
ADM (HGNC Symbol)
Adrenomedullin (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]