We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
ADM
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADM

Gene description

Adrenomedullin

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-138 MG)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression and extracellular positivity in several tissues, including placenta, appendix and esophagus.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Approved based on 1 antibody.
CAB016075
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB016075

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of gastric cancers as well as several colorectal and urothelial cancers showed moderate to strong positivity. Most endometrial cancers and cases of several other cancers including prostate and renal cancers were moderately stained. Cancer tissues were in general negative.

GENE INFORMATION

Gene name

ADM (HGNC Symbol)

Synonyms

AM

Description

Adrenomedullin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

10304680 - 10307397

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148926 (version 83.38)

Entrez gene

133

UniProt

P35318 (UniProt - Evidence at protein level)

neXtProt

NX_P35318

Antibodypedia

ADM antibodies

PROTEIN BROWSER

ADM-001
ADM-002
ADM-003
ADM-004
ADM-005
ADM-006
ADM-007
ADM-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADM-001
ENSP00000278175
ENST00000278175
P35318 [Direct mapping]
ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0002031 [G-protein coupled receptor internalization]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006171 [cAMP biosynthetic process]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008015 [blood circulation]
GO:0019731 [antibacterial humoral response]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031623 [receptor internalization]
GO:0045906 [negative regulation of vasoconstriction]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
185 aa
20.4 kDa
Yes 0
ADM-002
ENSP00000436607
ENST00000528655
P35318 [Direct mapping]
ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001843 [neural tube closure]
GO:0002026 [regulation of the force of heart contraction]
GO:0002031 [G-protein coupled receptor internalization]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006171 [cAMP biosynthetic process]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007507 [heart development]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0008015 [blood circulation]
GO:0008209 [androgen metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009409 [response to cold]
GO:0009611 [response to wounding]
GO:0010033 [response to organic substance]
GO:0010460 [positive regulation of heart rate]
GO:0019731 [antibacterial humoral response]
GO:0019933 [cAMP-mediated signaling]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031100 [organ regeneration]
GO:0031102 [neuron projection regeneration]
GO:0031623 [receptor internalization]
GO:0031700 [adrenomedullin receptor binding]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042594 [response to starvation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043116 [negative regulation of vascular permeability]
GO:0045766 [positive regulation of angiogenesis]
GO:0045906 [negative regulation of vasoconstriction]
GO:0045909 [positive regulation of vasodilation]
GO:0046879 [hormone secretion]
GO:0048589 [developmental growth]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051384 [response to glucocorticoid]
GO:0055074 [calcium ion homeostasis]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060712 [spongiotrophoblast layer development]
GO:0097084 [vascular smooth muscle cell development]
GO:2001214 [positive regulation of vasculogenesis]
Show all
185 aa
20.4 kDa
Yes 0
ADM-003
ENSP00000431438
ENST00000534464
E9PL83 [Direct mapping]
ADM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
138 aa
15.1 kDa
No 0
ADM-004
ENSP00000436837
ENST00000530439
E9PQE6 [Direct mapping]
ADM
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
117 aa
12.9 kDa
No 0
ADM-005
ENSP00000433062
ENST00000524948
E9PML4 [Direct mapping]
ADM
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
83 aa
9.2 kDa
Yes 0
ADM-006
ENSP00000434354
ENST00000526492
E9PQT2 [Direct mapping]
ADM
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
139 aa
15.2 kDa
Yes 0
ADM-007
ENSP00000435124
ENST00000525063
P35318 [Direct mapping]
ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0002031 [G-protein coupled receptor internalization]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006171 [cAMP biosynthetic process]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008015 [blood circulation]
GO:0019731 [antibacterial humoral response]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031623 [receptor internalization]
GO:0045906 [negative regulation of vasoconstriction]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
185 aa
20.4 kDa
Yes 0
ADM-008
ENSP00000434749
ENST00000528544
E9PML4 [Direct mapping]
ADM
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
83 aa
9.2 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.