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GAS2

GENERAL INFORMATION

Gene name

 GAS2

Gene description

 Growth arrest-specific 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Group enriched (Hep G2, Karpas-707, SCLC-21H, U-266/84)
HPA (normal tissue):Tissue enhanced (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA058904
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA058904

GENE INFORMATION

Gene name

 GAS2

Synonyms

Description

 Growth arrest-specific 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

Chromosome

 11

Cytoband

 p14.3

Chromosome location (bp)

 22625642 - 22813055

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148935 (version 83.38)

Entrez gene

 2620

UniProt

 O43903 (UniProt - Evidence at protein level)

neXtProt

 NX_O43903

Antibodypedia

 GAS2 antibodies

PROTEIN BROWSER
GAS2-001
GAS2-002
GAS2-005
GAS2-006
GAS2-007
GAS2-010
GAS2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAS2-001
ENSP00000401145
ENST00000454584
O43903 [Direct mapping]
Growth arrest-specific protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007050 [cell cycle arrest]
GO:0008360 [regulation of cell shape]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
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 313 aa
34.9 kDa 		No 0
GAS2-002
ENSP00000278187
ENST00000278187
O43903 [Direct mapping]
Growth arrest-specific protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007050 [cell cycle arrest]
GO:0008360 [regulation of cell shape]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
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 313 aa
34.9 kDa 		No 0
GAS2-005
ENSP00000435946
ENST00000532398
E9PRR5 [Direct mapping]
Growth arrest-specific protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 205 aa
22.6 kDa 		No 0
GAS2-006
ENSP00000433182
ENST00000534801
E9PM28 [Direct mapping]
Growth arrest-specific protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 155 aa
17.4 kDa 		No 0
GAS2-007
ENSP00000434478
ENST00000533363
E9PQ37 [Direct mapping]
Growth arrest-specific protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 136 aa
15.2 kDa 		No 0
GAS2-010
ENSP00000432584
ENST00000528582
E9PQ74 [Direct mapping]
Growth arrest-specific protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 181 aa
20.2 kDa 		No 0
GAS2-201
ENSP00000485708
ENST00000630668
O43903 [Direct mapping]
Growth arrest-specific protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007050 [cell cycle arrest]
GO:0008360 [regulation of cell shape]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
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 141 aa
15.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.