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DGKZ

GENERAL INFORMATION

Gene name

 DGKZ

Gene description

 Diacylglycerol kinase, zeta

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in neuronal cells, most abundant in cerebellum.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA051336
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051336

GENE INFORMATION

Gene name

 DGKZ (HGNC Symbol)

Synonyms

 DAGK5, DAGK6, DGK-ZETA, hDGKzeta

Description

 Diacylglycerol kinase, zeta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 46332905 - 46380554

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149091 (version 83.38)

Entrez gene

 8525

UniProt

 Q13574 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13574

Antibodypedia

 DGKZ antibodies

PROTEIN BROWSER
«
DGKZ-001
DGKZ-002
DGKZ-003
DGKZ-005
DGKZ-008
DGKZ-012
DGKZ-013
DGKZ-018
DGKZ-022
DGKZ-023
DGKZ-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGKZ-001
ENSP00000343065
ENST00000343674
Q13574 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001727 [lipid kinase activity]
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046834 [lipid phosphorylation]
GO:0046872 [metal ion binding]
Show all
 945 aa
106 kDa 		No 0
DGKZ-002
ENSP00000412178
ENST00000454345
Q13574 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001727 [lipid kinase activity]
GO:0004143 [diacylglycerol kinase activity]
GO:0004857 [enzyme inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046834 [lipid phosphorylation]
GO:0046872 [metal ion binding]
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 1117 aa
124.1 kDa 		No 0
DGKZ-003
ENSP00000434719
ENST00000528615
E9PNL8 [Direct mapping]
Diacylglycerol kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
 707 aa
78.9 kDa 		No 0
DGKZ-005
ENSP00000436273
ENST00000532868
Q13574 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001727 [lipid kinase activity]
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046834 [lipid phosphorylation]
GO:0046872 [metal ion binding]
Show all
 933 aa
104.3 kDa 		No 0
DGKZ-008
ENSP00000436291
ENST00000527911
Q13574 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001727 [lipid kinase activity]
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046834 [lipid phosphorylation]
GO:0046872 [metal ion binding]
Show all
 934 aa
104.6 kDa 		No 0
DGKZ-012
ENSP00000435332
ENST00000525242
E9PKT3 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 17 aa
1.9 kDa 		No 0
DGKZ-013
ENSP00000435763
ENST00000524448
H0YEG2 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
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 98 aa
11.6 kDa 		No 0
DGKZ-018
ENSP00000434016
ENST00000524869
H0YDN6 [Direct mapping]
Diacylglycerol kinase zeta
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016310 [phosphorylation]
Show all
 197 aa
21.7 kDa 		No 0
DGKZ-022
ENSP00000395684
ENST00000456247
Q13574 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001727 [lipid kinase activity]
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046834 [lipid phosphorylation]
GO:0046872 [metal ion binding]
Show all
 928 aa
104 kDa 		No 0
DGKZ-023
ENSP00000391021
ENST00000421244
Q13574 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001727 [lipid kinase activity]
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046834 [lipid phosphorylation]
GO:0046872 [metal ion binding]
Show all
 929 aa
104.1 kDa 		No 0
DGKZ-024
ENSP00000320340
ENST00000318201
Q13574 [Direct mapping]
Diacylglycerol kinase zeta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001727 [lipid kinase activity]
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046834 [lipid phosphorylation]
GO:0046872 [metal ion binding]
Show all
 906 aa
101.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.