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Most malignant cells exhibited moderate cytoplasmic staining. Several cases of colorectal and endometrial cancers showed strong immunoreactivity. Malignant gliomas and renal cancers were negative or showed weak staining.
GENE INFORMATION
Gene name
EIF3M (HGNC Symbol)
Synonyms
eIF3m, FLJ29030, GA17, hfl-B5, PCID1, TANGO7
Description
Eukaryotic translation initiation factor 3, subunit M (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]