Tissue expression of GLYAT - Summary - The Human Protein Atlas

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GLYAT

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GLYAT
Gene description	Glycine-N-acyltransferase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (kidney, liver)
GTEx:	Group enriched (kidney, liver)
FANTOM5:	Group enriched (kidney, liver)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in renal tubules, hepatocytes and epididymis.". Rewrite!

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA040251 , HPA044094
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)

GENE INFORMATION
Gene name	GLYAT (HGNC Symbol)
Synonyms	ACGNAT, GAT
Description	Glycine-N-acyltransferase (HGNC Symbol)
Entrez gene summary	The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	58640426 - 58731974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149124 (version 83.38)
Entrez gene	10249
UniProt	Q6IB77 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IB77
Antibodypedia	GLYAT antibodies

PROTEIN BROWSER

GLYAT-001	GLYAT-002	GLYAT-004	GLYAT-005	GLYAT-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLYAT-001 ENSP00000278400 ENST00000278400	Q6IB77 [Direct mapping] Glycine N-acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006544 [glycine metabolic process] GO:0006637 [acyl-CoA metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0016746 [transferase activity, transferring acyl groups] GO:0032787 [monocarboxylic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047961 [glycine N-acyltransferase activity] GO:0047962 [glycine N-benzoyltransferase activity] GO:0070062 [extracellular exosome] Show all	163 aa 18.5 kDa	No	0
GLYAT-002 ENSP00000340200 ENST00000344743	Q6IB77 [Direct mapping] Glycine N-acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006544 [glycine metabolic process] GO:0006637 [acyl-CoA metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0016746 [transferase activity, transferring acyl groups] GO:0032787 [monocarboxylic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047961 [glycine N-acyltransferase activity] GO:0047962 [glycine N-benzoyltransferase activity] GO:0070062 [extracellular exosome] Show all	296 aa 33.9 kDa	No	0
GLYAT-004 ENSP00000431688 ENST00000529732	Q6IB77 [Direct mapping] Glycine N-acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006544 [glycine metabolic process] GO:0006637 [acyl-CoA metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0016746 [transferase activity, transferring acyl groups] GO:0032787 [monocarboxylic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047961 [glycine N-acyltransferase activity] GO:0047962 [glycine N-benzoyltransferase activity] GO:0070062 [extracellular exosome] Show all	296 aa 33.9 kDa	No	0
GLYAT-005 ENSP00000468512 ENST00000586098	K7ES21 [Direct mapping] Glycine N-acyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0047961 [glycine N-acyltransferase activity] Show all	71 aa 7.9 kDa	No	0
GLYAT-201 ENSP00000484592 ENST00000611865	Q6IB77 [Direct mapping] Glycine N-acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006544 [glycine metabolic process] GO:0006637 [acyl-CoA metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0009636 [response to toxic substance] GO:0016746 [transferase activity, transferring acyl groups] GO:0032787 [monocarboxylic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047961 [glycine N-acyltransferase activity] GO:0047962 [glycine N-benzoyltransferase activity] GO:0070062 [extracellular exosome] Show all	296 aa 33.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.