Expression of C11orf73 in cancer - Summary - The Human Protein Atlas

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C11orf73

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C11orf73
Gene description	Chromosome 11 open reading frame 73
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA035063 , HPA035064
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035063	HPA035064

GENE INFORMATION
Gene name	C11orf73 (HGNC Symbol)
Synonyms	Hikeshi, HSPC138, HSPC179, OPI10
Description	Chromosome 11 open reading frame 73 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q14.2
Chromosome location (bp)	86302211 - 86345931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149196 (version 83.38)
Entrez gene	51501
UniProt	Q53FT3 (UniProt - Evidence at protein level)
neXtProt	NX_Q53FT3
Antibodypedia	C11orf73 antibodies

PROTEIN BROWSER

C11orf73-001	C11orf73-002	C11orf73-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C11orf73-001 ENSP00000278483 ENST00000278483	Q53FT3 [Direct mapping] Protein Hikeshi Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0007030 [Golgi organization] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0030054 [cell junction] GO:0030324 [lung development] GO:0030544 [Hsp70 protein binding] GO:0034605 [cellular response to heat] GO:0070062 [extracellular exosome] GO:1900034 [regulation of cellular response to heat] Show all	197 aa 21.6 kDa	No	0
C11orf73-002 ENSP00000432699 ENST00000533986	E9PPG8 [Direct mapping] Protein Hikeshi Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0030054 [cell junction] Show all	194 aa 21.1 kDa	No	0
C11orf73-201 ENSP00000482151 ENST00000618164	A0A087WYW7 [Direct mapping] Protein Hikeshi Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 14.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.