Expression of KLHL35 in cancer - Summary - The Human Protein Atlas

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KLHL35

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KLHL35
Gene description	Kelch-like family member 35
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CACO-2, HMC-1, PC-3, SiHa)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA039232 , HPA039864
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039232	HPA039864

GENE INFORMATION
Gene name	KLHL35 (HGNC Symbol)
Synonyms	FLJ33790
Description	Kelch-like family member 35 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	75422394 - 75430629
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149243 (version 83.38)
Entrez gene	283212
UniProt	Q6PF15 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PF15
Antibodypedia	KLHL35 antibodies

PROTEIN BROWSER

KLHL35-002	KLHL35-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHL35-002 ENSP00000365469 ENST00000376292	A0A0C4DFW7 [Direct mapping] Kelch-like protein 35 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	363 aa 40 kDa	No	0
KLHL35-201 ENSP00000438526 ENST00000539798	Q6PF15 [Direct mapping] Kelch-like protein 35 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	583 aa 62.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.