Expression of SERPINH1 in cancer - Summary

GENERAL INFORMATION
Gene name	SERPINH1
Gene description	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues with additional positivity in extracellular matrix.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA029198 , CAB004441
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), head and neck cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA029198	CAB004441

GENE INFORMATION
Gene name	SERPINH1 (HGNC Symbol)
Synonyms	CBP1, CBP2, colligen, HSP47, SERPINH2
Description	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Chromosome	11
Cytoband	q13.5
Chromosome location (bp)	75562056 - 75572783
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149257 (version 83.38)
Entrez gene	871
UniProt	P50454 (UniProt - Evidence at protein level)
neXtProt	NX_P50454
Antibodypedia	SERPINH1 antibodies

PROTEIN BROWSER

SERPINH1-001	SERPINH1-003	SERPINH1-004	SERPINH1-006	SERPINH1-009	SERPINH1-010	SERPINH1-011	SERPINH1-012	SERPINH1-013	SERPINH1-014	SERPINH1-015	SERPINH1-016	SERPINH1-017	SERPINH1-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINH1-001 ENSP00000434657 ENST00000533603	P50454 [Direct mapping] Serpin H1 A0A024R5K8 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade H (Heat shock protein 47), member 1, (Collagen binding protein 1), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0006986 [response to unfolded protein] GO:0010951 [negative regulation of endopeptidase activity] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0044822 [poly(A) RNA binding] GO:0045121 [membrane raft] GO:0070062 [extracellular exosome] Show all	418 aa 46.4 kDa	Yes	0
SERPINH1-003 ENSP00000436305 ENST00000530284	E9PPV6 [Direct mapping] Serpin H1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	324 aa 35.7 kDa	Yes	0
SERPINH1-004 ENSP00000350894 ENST00000358171	P50454 [Direct mapping] Serpin H1 A0A024R5K8 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade H (Heat shock protein 47), member 1, (Collagen binding protein 1), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0006986 [response to unfolded protein] GO:0010951 [negative regulation of endopeptidase activity] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0044822 [poly(A) RNA binding] GO:0045121 [membrane raft] GO:0070062 [extracellular exosome] Show all	418 aa 46.4 kDa	Yes	0
SERPINH1-006 ENSP00000434412 ENST00000524558	P50454 [Direct mapping] Serpin H1 A0A024R5K8 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade H (Heat shock protein 47), member 1, (Collagen binding protein 1), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003433 [chondrocyte development involved in endochondral bone morphogenesis] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0006986 [response to unfolded protein] GO:0010951 [negative regulation of endopeptidase activity] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0032964 [collagen biosynthetic process] GO:0044822 [poly(A) RNA binding] GO:0045121 [membrane raft] GO:0051082 [unfolded protein binding] GO:0051604 [protein maturation] GO:0070062 [extracellular exosome] Show all	418 aa 46.4 kDa	Yes	0
SERPINH1-009 ENSP00000433532 ENST00000525876	E9PKH2 [Direct mapping] Serpin H1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	201 aa 23.1 kDa	No	0
SERPINH1-010 ENSP00000431384 ENST00000526242	E9PLA6 [Direct mapping] Serpin H1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	86 aa 8.9 kDa	Yes	0
SERPINH1-011 ENSP00000434964 ENST00000526397	E9PMI5 [Direct mapping] Serpin H1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	249 aa 27.2 kDa	Yes	0
SERPINH1-012 ENSP00000435936 ENST00000529643	E9PRS3 [Direct mapping] Serpin H1 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	167 aa 17.6 kDa	Yes	0
SERPINH1-013 ENSP00000434482 ENST00000525492	E9PQ34 [Direct mapping] Serpin H1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	142 aa 15.3 kDa	Yes	0
SERPINH1-014 ENSP00000432007 ENST00000528990	E9PIG2 [Direct mapping] Serpin H1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	165 aa 17.4 kDa	Yes	0
SERPINH1-015 ENSP00000431827 ENST00000533449	E9PJH8 [Direct mapping] Serpin H1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	150 aa 15.5 kDa	Yes	0
SERPINH1-016 ENSP00000435452 ENST00000525611	E9PK86 [Direct mapping] Serpin H1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	247 aa 27 kDa	Yes	0
SERPINH1-017 ENSP00000437108 ENST00000528760	E9PNX1 [Direct mapping] Serpin H1 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	203 aa 21.5 kDa	Yes	0
SERPINH1-018 ENSP00000436040 ENST00000532356	E9PR70 [Direct mapping] Serpin H1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005518 [collagen binding] GO:0005783 [endoplasmic reticulum] GO:0010951 [negative regulation of endopeptidase activity] GO:0030199 [collagen fibril organization] Show all	295 aa 32.6 kDa	Yes	0