Expression of CAPN5 in cancer - Summary

GENERAL INFORMATION
Gene name	CAPN5
Gene description	Calpain 5
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues, most abundant in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB033237
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB033237

GENE INFORMATION
Gene name	CAPN5 (HGNC Symbol)
Synonyms	ADNIV, HTRA3, nCL-3, VRNI
Description	Calpain 5 (HGNC Symbol)
Entrez gene summary	Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.5
Chromosome location (bp)	77066932 - 77126155
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149260 (version 83.38)
Entrez gene	726
UniProt	O15484 (UniProt - Evidence at protein level)
neXtProt	NX_O15484
Antibodypedia	CAPN5 antibodies

PROTEIN BROWSER

CAPN5-001	CAPN5-003	CAPN5-004	CAPN5-006	CAPN5-007	CAPN5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPN5-001 ENSP00000278559 ENST00000278559	O15484 [Direct mapping] Calpain-5 Show all	Enzymes Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001541 [ovarian follicle development] GO:0001553 [luteinization] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0060014 [granulosa cell differentiation] GO:0070062 [extracellular exosome] Show all	640 aa 73.2 kDa	No	0
CAPN5-003 ENSP00000432332 ENST00000529629	O15484 [Direct mapping] Calpain-5 Show all	Enzymes Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0070062 [extracellular exosome] Show all	640 aa 73.2 kDa	No	0
CAPN5-004 ENSP00000409996 ENST00000456580	E7EV01 [Direct mapping] Calpain-5 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	680 aa 77.5 kDa	No	0
CAPN5-006 ENSP00000467244 ENST00000531028	K7EP62 [Direct mapping] Calpain-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	52 aa 6.1 kDa	No	0
CAPN5-007 ENSP00000435894 ENST00000527066	E9PS73 [Direct mapping] Calpain-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	97 aa 11.1 kDa	No	0
CAPN5-201 ENSP00000483282 ENST00000615896	A0A087X0C8 [Direct mapping] Calpain-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	639 aa 73 kDa	No	0