Expression of INTS4 in cancer - Summary - The Human Protein Atlas

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INTS4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	INTS4
Gene description	Integrator complex subunit 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA042378
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and thyroid cancer (favourable).
Liver cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042378

GENE INFORMATION
Gene name	INTS4 (HGNC Symbol)
Synonyms	INT4, MGC16733, MST093
Description	Integrator complex subunit 4 (HGNC Symbol)
Entrez gene summary	INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Chromosome	11
Cytoband	q14.1
Chromosome location (bp)	77878720 - 77994678
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149262 (version 83.38)
Entrez gene	92105
UniProt	Q96HW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HW7
Antibodypedia	INTS4 antibodies

PROTEIN BROWSER

INTS4-001	INTS4-003	INTS4-004	INTS4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INTS4-001 ENSP00000434466 ENST00000534064	Q96HW7 [Direct mapping] Integrator complex subunit 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	963 aa 108.2 kDa	No	0
INTS4-003 ENSP00000433644 ENST00000529807	Q96HW7 [Direct mapping] Integrator complex subunit 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	505 aa 56.5 kDa	No	0
INTS4-004 ENSP00000435758 ENST00000527522	E9PIM3 [Direct mapping] Integrator complex subunit 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.9 kDa	No	0
INTS4-201 ENSP00000441084 ENST00000535943	Q96HW7 [Direct mapping] Integrator complex subunit 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	338 aa 38.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.