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PAK1

GENERAL INFORMATION

Gene name

 PAK1

Gene description

 P21 protein (Cdc42/Rac)-activated kinase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues. High expression in neuronal cells of the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003565 , CAB005312
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable) and colorectal cancer (favourable).
Glioma p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003565
CAB005312

GENE INFORMATION

Gene name

 PAK1

Synonyms

Description

 P21 protein (Cdc42/Rac)-activated kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Chromosome

 11

Cytoband

Chromosome location (bp)

 77321707 - 77474635

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149269 (version 83.38)

Entrez gene

 5058

UniProt

 Q13153 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13153

Antibodypedia

 PAK1 antibodies

PROTEIN BROWSER
PAK1-001
PAK1-002
PAK1-003
PAK1-004
PAK1-006
PAK1-007
PAK1-009
PAK1-010
PAK1-011
PAK1-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAK1-001
ENSP00000348696
ENST00000356341
Q13153 [Direct mapping]
Serine/threonine-protein kinase PAK 1
A0A024R5P0 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0006915 [apoptotic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007411 [axon guidance]
GO:0014704 [intercalated disc]
GO:0016477 [cell migration]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031941 [filamentous actin]
GO:0031965 [nuclear membrane]
GO:0032147 [activation of protein kinase activity]
GO:0032587 [ruffle membrane]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042060 [wound healing]
GO:0042981 [regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048812 [neuron projection morphogenesis]
GO:0050852 [T cell receptor signaling pathway]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0060244 [negative regulation of cell proliferation involved in contact inhibition]
GO:0071437 [invadopodium]
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 545 aa
60.6 kDa 		No 0
PAK1-002
ENSP00000278568
ENST00000278568
Q13153 [Direct mapping]
Serine/threonine-protein kinase PAK 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001726 [ruffle]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0006915 [apoptotic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007411 [axon guidance]
GO:0007528 [neuromuscular junction development]
GO:0010033 [response to organic substance]
GO:0010468 [regulation of gene expression]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0019901 [protein kinase binding]
GO:0021764 [amygdala development]
GO:0030018 [Z disc]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031941 [filamentous actin]
GO:0031965 [nuclear membrane]
GO:0032147 [activation of protein kinase activity]
GO:0032587 [ruffle membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042060 [wound healing]
GO:0042981 [regulation of apoptotic process]
GO:0043113 [receptor clustering]
GO:0043234 [protein complex]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048812 [neuron projection morphogenesis]
GO:0050852 [T cell receptor signaling pathway]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0060244 [negative regulation of cell proliferation involved in contact inhibition]
GO:0060996 [dendritic spine development]
GO:0061534 [gamma-aminobutyric acid secretion, neurotransmission]
GO:0061535 [glutamate secretion, neurotransmission]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071437 [invadopodium]
GO:0097481 [neuronal postsynaptic density]
GO:0098597 [observational learning]
GO:1900271 [regulation of long-term synaptic potentiation]
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 553 aa
61.6 kDa 		No 0
PAK1-003
ENSP00000433423
ENST00000530617
B3KNX7 [Direct mapping]
Non-specific serine/threonine protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 522 aa
58.2 kDa 		No 0
PAK1-004
ENSP00000433211
ENST00000528203
E9PM17 [Direct mapping]
Non-specific serine/threonine protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 455 aa
50.9 kDa 		No 0
PAK1-006
ENSP00000433737
ENST00000526968
E9PJF8 [Direct mapping]
Serine/threonine-protein kinase PAK 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 26 aa
2.8 kDa 		No 0
PAK1-007
ENSP00000432477
ENST00000524847
E9PQW5 [Direct mapping]
Serine/threonine-protein kinase PAK 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 99 aa
10.9 kDa 		No 0
PAK1-009
ENSP00000433518
ENST00000529248
E9PKH9 [Direct mapping]
Serine/threonine-protein kinase PAK 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 106 aa
11.8 kDa 		No 0
PAK1-010
ENSP00000435983
ENST00000528633
E9PRP6 [Direct mapping]
Serine/threonine-protein kinase PAK 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 63 aa
6.8 kDa 		No 0
PAK1-011
ENSP00000433004
ENST00000528592
E9PMP2 [Direct mapping]
Serine/threonine-protein kinase PAK 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 89 aa
9.9 kDa 		No 0
PAK1-018
ENSP00000431541
ENST00000533285
H0YCG5 [Direct mapping]
Serine/threonine-protein kinase PAK 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 244 aa
27.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.