Expression of NCAM1 in cancer - Summary

GENERAL INFORMATION
Gene name	NCAM1
Gene description	Neural cell adhesion molecule 1
Protein class	Cancer-related genes CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (RH-30, SCLC-21H, U-138 MG, WM-115)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in the CNS, peripheral nerves, adrenal gland, heart and gastric chief cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA039835 , CAB000142 , CAB018071
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA039835	CAB000142	CAB018071

GENE INFORMATION
Gene name	NCAM1 (HGNC Symbol)
Synonyms	CD56, NCAM
Description	Neural cell adhesion molecule 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
Chromosome	11
Cytoband	q23.2
Chromosome location (bp)	112961247 - 113278436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149294 (version 83.38)
Entrez gene	4684
UniProt	P13591 (UniProt - Evidence at protein level)
neXtProt	NX_P13591
Antibodypedia	NCAM1 antibodies

PROTEIN BROWSER

NCAM1-001	NCAM1-002	NCAM1-003	NCAM1-004	NCAM1-005	NCAM1-006	NCAM1-008	NCAM1-009	NCAM1-011	NCAM1-012	NCAM1-013	NCAM1-015	NCAM1-018	NCAM1-020	NCAM1-027	NCAM1-201	NCAM1-202	NCAM1-203	NCAM1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAM1-001 ENSP00000318472 ENST00000316851	P13591 [Direct mapping] Neural cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030198 [extracellular matrix organization] GO:0031225 [anchored component of membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular exosome] Show all	858 aa 94.6 kDa	Yes	1
NCAM1-002 ENSP00000480132 ENST00000619839	A0A087WWD4 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001928 [regulation of exocyst assembly] GO:0005515 [protein binding] GO:0005911 [cell-cell junction] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031175 [neuron projection development] GO:0034109 [homotypic cell-cell adhesion] GO:0043025 [neuronal cell body] GO:0050850 [positive regulation of calcium-mediated signaling] Show all	884 aa 97.3 kDa	Yes	1
NCAM1-003 ENSP00000481083 ENST00000621128	P13591 [Direct mapping] Neural cell adhesion molecule 1 Show all	CD markers MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030198 [extracellular matrix organization] GO:0031225 [anchored component of membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular exosome] Show all	726 aa 80.3 kDa	Yes	0
NCAM1-004 ENSP00000484943 ENST00000531044	P13591 [Direct mapping] Neural cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030198 [extracellular matrix organization] GO:0031225 [anchored component of membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular exosome] Show all	848 aa 93.4 kDa	Yes	1
NCAM1-005 ENSP00000482205 ENST00000529356	P13591 [Direct mapping] Neural cell adhesion molecule 1 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030198 [extracellular matrix organization] GO:0031225 [anchored component of membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular exosome] Show all	364 aa 40.8 kDa	Yes	0
NCAM1-006 ENSP00000480774 ENST00000621850	P13591 [Direct mapping] Neural cell adhesion molecule 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030198 [extracellular matrix organization] GO:0031225 [anchored component of membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular exosome] Show all	761 aa 83.8 kDa	Yes	1
NCAM1-008 ENSP00000384055 ENST00000401611	H7BYX6 [Direct mapping] Neural cell adhesion molecule 1 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] Show all	725 aa 80.3 kDa	Yes	0
NCAM1-009 ENSP00000479687 ENST00000526322	A0A087WVU1 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	305 aa 33 kDa	No	1
NCAM1-011 ENSP00000486406 ENST00000533073	A0A0D9SF98 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	357 aa 38.6 kDa	No	1
NCAM1-012 ENSP00000480269 ENST00000528590	A0A087WWJ5 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	372 aa 39.9 kDa	No	1
NCAM1-013 ENSP00000486241 ENST00000528158	A0A0D9SF30 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	468 aa 47 kDa	No	1
NCAM1-015 ENSP00000482852 ENST00000620046	A0A087WZS4 [Direct mapping] Neural cell adhesion molecule 1 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	136 aa 14.8 kDa	Yes	0
NCAM1-018 ENSP00000479353 ENST00000613217	A0A087WVD0 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	133 aa 14.9 kDa	Yes	0
NCAM1-020 ENSP00000484481 ENST00000530543	A0A087X1V2 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	229 aa 25.2 kDa	No	0
NCAM1-027 ENSP00000478072 ENST00000524916	A0A087WTR3 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	84 aa 9.4 kDa	No	0
NCAM1-201 ENSP00000480797 ENST00000615112	A0A087WX77 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	858 aa 94.5 kDa	Yes	1
NCAM1-202 ENSP00000479241 ENST00000615285	A0A087WV75 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	884 aa 97.3 kDa	Yes	1
NCAM1-203 ENSP00000477835 ENST00000618266	A0A087WTF6 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	848 aa 93.3 kDa	Yes	1
NCAM1-204 ENSP00000477808 ENST00000621518	A0A087WTE4 [Direct mapping] Neural cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	761 aa 83.7 kDa	Yes	1