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DRD2

GENERAL INFORMATION

Gene name

 DRD2

Gene description

 Dopamine receptor D2

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in the brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Pending additional tissues.

Reliability score

 Supported based on 1 antibody.
HPA015691
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015691

GENE INFORMATION

Gene name

 DRD2

Synonyms

Description

 Dopamine receptor D2 (HGNC Symbol)

Entrez gene summary

 This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q23.2

Chromosome location (bp)

 113409615 - 113475691

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149295 (version 83.38)

Entrez gene

 1813

UniProt

 P14416 (UniProt - Evidence at protein level)

neXtProt

 NX_P14416

Antibodypedia

 DRD2 antibodies

PROTEIN BROWSER
DRD2-001
DRD2-003
DRD2-004
DRD2-005
DRD2-006
DRD2-007
DRD2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DRD2-001
ENSP00000354859
ENST00000362072
P14416 [Direct mapping]
D(2) dopamine receptor
A0A024R3C5 [Target identity:100%; Query identity:100%]
Dopamine receptor D2, isoform CRA_c
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001591 [dopamine neurotransmitter receptor activity, coupled via Gi/Go]
GO:0001659 [temperature homeostasis]
GO:0001666 [response to hypoxia]
GO:0001669 [acrosomal vesicle]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001964 [startle response]
GO:0001975 [response to amphetamine]
GO:0001976 [neurological system process involved in regulation of systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002028 [regulation of sodium ion transport]
GO:0002031 [G-protein coupled receptor internalization]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0004930 [G-protein coupled receptor activity]
GO:0004952 [dopamine neurotransmitter receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007212 [dopamine receptor signaling pathway]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007409 [axonogenesis]
GO:0007416 [synapse assembly]
GO:0007608 [sensory perception of smell]
GO:0007616 [long-term memory]
GO:0007625 [grooming behavior]
GO:0007626 [locomotory behavior]
GO:0007628 [adult walking behavior]
GO:0007631 [feeding behavior]
GO:0008104 [protein localization]
GO:0008144 [drug binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008306 [associative learning]
GO:0008542 [visual learning]
GO:0009416 [response to light stimulus]
GO:0009636 [response to toxic substance]
GO:0010039 [response to iron ion]
GO:0014059 [regulation of dopamine secretion]
GO:0014069 [postsynaptic density]
GO:0014854 [response to inactivity]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0021756 [striatum development]
GO:0021769 [orbitofrontal cortex development]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0021984 [adenohypophysis development]
GO:0030139 [endocytic vesicle]
GO:0030336 [negative regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030432 [peristalsis]
GO:0030534 [adult behavior]
GO:0030672 [synaptic vesicle membrane]
GO:0030814 [regulation of cAMP metabolic process]
GO:0030900 [forebrain development]
GO:0031223 [auditory behavior]
GO:0031410 [cytoplasmic vesicle]
GO:0031513 [nonmotile primary cilium]
GO:0032147 [activation of protein kinase activity]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032467 [positive regulation of cytokinesis]
GO:0032922 [circadian regulation of gene expression]
GO:0033602 [negative regulation of dopamine secretion]
GO:0034776 [response to histamine]
GO:0035094 [response to nicotine]
GO:0035240 [dopamine binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0035810 [positive regulation of urine volume]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0036126 [sperm flagellum]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042220 [response to cocaine]
GO:0042321 [negative regulation of circadian sleep/wake cycle, sleep]
GO:0042417 [dopamine metabolic process]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0043266 [regulation of potassium ion transport]
GO:0043278 [response to morphine]
GO:0043408 [regulation of MAPK cascade]
GO:0043473 [pigmentation]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0043679 [axon terminus]
GO:0045471 [response to ethanol]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:0045776 [negative regulation of blood pressure]
GO:0045824 [negative regulation of innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0046676 [negative regulation of insulin secretion]
GO:0046717 [acid secretion]
GO:0046982 [protein heterodimerization activity]
GO:0048148 [behavioral response to cocaine]
GO:0048149 [behavioral response to ethanol]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048678 [response to axon injury]
GO:0048755 [branching morphogenesis of a nerve]
GO:0050482 [arachidonic acid secretion]
GO:0050709 [negative regulation of protein secretion]
GO:0050804 [modulation of synaptic transmission]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0051586 [positive regulation of dopamine uptake involved in synaptic transmission]
GO:0051823 [regulation of synapse structural plasticity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0060124 [positive regulation of growth hormone secretion]
GO:0060134 [prepulse inhibition]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
GO:0060160 [negative regulation of dopamine receptor signaling pathway]
GO:0060170 [ciliary membrane]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090325 [regulation of locomotion involved in locomotory behavior]
GO:1900168 [positive regulation of glial cell-derived neurotrophic factor secretion]
GO:1900273 [positive regulation of long-term synaptic potentiation]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
Show all
 443 aa
50.6 kDa 		No 7
DRD2-003
ENSP00000278597
ENST00000346454
P14416 [Direct mapping]
D(2) dopamine receptor
A0A024R3I6 [Target identity:100%; Query identity:100%]
Dopamine receptor D2, isoform CRA_b
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001591 [dopamine neurotransmitter receptor activity, coupled via Gi/Go]
GO:0001659 [temperature homeostasis]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001975 [response to amphetamine]
GO:0001976 [neurological system process involved in regulation of systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002028 [regulation of sodium ion transport]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007409 [axonogenesis]
GO:0007416 [synapse assembly]
GO:0007608 [sensory perception of smell]
GO:0007626 [locomotory behavior]
GO:0007628 [adult walking behavior]
GO:0008104 [protein localization]
GO:0008144 [drug binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008306 [associative learning]
GO:0008542 [visual learning]
GO:0009416 [response to light stimulus]
GO:0009636 [response to toxic substance]
GO:0014059 [regulation of dopamine secretion]
GO:0015459 [potassium channel regulator activity]
GO:0016021 [integral component of membrane]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0021984 [adenohypophysis development]
GO:0030336 [negative regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030432 [peristalsis]
GO:0030672 [synaptic vesicle membrane]
GO:0030814 [regulation of cAMP metabolic process]
GO:0031513 [nonmotile primary cilium]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032467 [positive regulation of cytokinesis]
GO:0032922 [circadian regulation of gene expression]
GO:0034776 [response to histamine]
GO:0035240 [dopamine binding]
GO:0035556 [intracellular signal transduction]
GO:0042220 [response to cocaine]
GO:0042417 [dopamine metabolic process]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0043266 [regulation of potassium ion transport]
GO:0043278 [response to morphine]
GO:0045776 [negative regulation of blood pressure]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0048148 [behavioral response to cocaine]
GO:0048149 [behavioral response to ethanol]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048755 [branching morphogenesis of a nerve]
GO:0050482 [arachidonic acid secretion]
GO:0050709 [negative regulation of protein secretion]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0051586 [positive regulation of dopamine uptake involved in synaptic transmission]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0060124 [positive regulation of growth hormone secretion]
GO:0060134 [prepulse inhibition]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
GO:0060160 [negative regulation of dopamine receptor signaling pathway]
GO:0060170 [ciliary membrane]
GO:1900168 [positive regulation of glial cell-derived neurotrophic factor secretion]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
Show all
 414 aa
47.3 kDa 		No 7
DRD2-004
ENSP00000442172
ENST00000542968
P14416 [Direct mapping]
D(2) dopamine receptor
A0A024R3C5 [Target identity:100%; Query identity:100%]
Dopamine receptor D2, isoform CRA_c
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001591 [dopamine neurotransmitter receptor activity, coupled via Gi/Go]
GO:0001659 [temperature homeostasis]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001975 [response to amphetamine]
GO:0001976 [neurological system process involved in regulation of systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002028 [regulation of sodium ion transport]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007409 [axonogenesis]
GO:0007416 [synapse assembly]
GO:0007608 [sensory perception of smell]
GO:0007626 [locomotory behavior]
GO:0007628 [adult walking behavior]
GO:0008104 [protein localization]
GO:0008144 [drug binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008306 [associative learning]
GO:0008542 [visual learning]
GO:0009416 [response to light stimulus]
GO:0009636 [response to toxic substance]
GO:0014059 [regulation of dopamine secretion]
GO:0015459 [potassium channel regulator activity]
GO:0016021 [integral component of membrane]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0021984 [adenohypophysis development]
GO:0030336 [negative regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030432 [peristalsis]
GO:0030672 [synaptic vesicle membrane]
GO:0030814 [regulation of cAMP metabolic process]
GO:0031513 [nonmotile primary cilium]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032467 [positive regulation of cytokinesis]
GO:0032922 [circadian regulation of gene expression]
GO:0034776 [response to histamine]
GO:0035240 [dopamine binding]
GO:0035556 [intracellular signal transduction]
GO:0042220 [response to cocaine]
GO:0042417 [dopamine metabolic process]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0043266 [regulation of potassium ion transport]
GO:0043278 [response to morphine]
GO:0045776 [negative regulation of blood pressure]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0048148 [behavioral response to cocaine]
GO:0048149 [behavioral response to ethanol]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048755 [branching morphogenesis of a nerve]
GO:0050482 [arachidonic acid secretion]
GO:0050709 [negative regulation of protein secretion]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0051586 [positive regulation of dopamine uptake involved in synaptic transmission]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0060124 [positive regulation of growth hormone secretion]
GO:0060134 [prepulse inhibition]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
GO:0060160 [negative regulation of dopamine receptor signaling pathway]
GO:0060170 [ciliary membrane]
GO:1900168 [positive regulation of glial cell-derived neurotrophic factor secretion]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
Show all
 443 aa
50.6 kDa 		No 7
DRD2-005
ENSP00000441068
ENST00000544518
F8VUV1 [Direct mapping]
D(2) dopamine receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001963 [synaptic transmission, dopaminergic]
GO:0004930 [G-protein coupled receptor activity]
GO:0004952 [dopamine neurotransmitter receptor activity]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0009636 [response to toxic substance]
GO:0014059 [regulation of dopamine secretion]
GO:0016021 [integral component of membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0035240 [dopamine binding]
GO:0042493 [response to drug]
GO:0043266 [regulation of potassium ion transport]
GO:0048148 [behavioral response to cocaine]
GO:0048149 [behavioral response to ethanol]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
Show all
 442 aa
50.5 kDa 		No 7
DRD2-006
ENSP00000441474
ENST00000542616
Predicted intracellular proteins
Show all
 7 aa
0.8 kDa 		No 0
DRD2-007
ENSP00000438419
ENST00000543292
Q6LDH7 [Direct mapping]
D(2) dopamine receptor; Dopamine D2 receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0001963 [synaptic transmission, dopaminergic]
GO:0004930 [G-protein coupled receptor activity]
GO:0004952 [dopamine neurotransmitter receptor activity]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007212 [dopamine receptor signaling pathway]
GO:0009636 [response to toxic substance]
GO:0014059 [regulation of dopamine secretion]
GO:0016021 [integral component of membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0035240 [dopamine binding]
GO:0042493 [response to drug]
GO:0043266 [regulation of potassium ion transport]
GO:0048148 [behavioral response to cocaine]
GO:0048149 [behavioral response to ethanol]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
Show all
 177 aa
20.1 kDa 		No 4
DRD2-010
ENSP00000438215
ENST00000538967
P14416 [Direct mapping]
D(2) dopamine receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001591 [dopamine neurotransmitter receptor activity, coupled via Gi/Go]
GO:0001659 [temperature homeostasis]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001975 [response to amphetamine]
GO:0001976 [neurological system process involved in regulation of systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002028 [regulation of sodium ion transport]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007270 [neuron-neuron synaptic transmission]
GO:0007409 [axonogenesis]
GO:0007416 [synapse assembly]
GO:0007608 [sensory perception of smell]
GO:0007626 [locomotory behavior]
GO:0007628 [adult walking behavior]
GO:0008104 [protein localization]
GO:0008144 [drug binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008306 [associative learning]
GO:0008542 [visual learning]
GO:0009416 [response to light stimulus]
GO:0009636 [response to toxic substance]
GO:0014059 [regulation of dopamine secretion]
GO:0015459 [potassium channel regulator activity]
GO:0016021 [integral component of membrane]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0021984 [adenohypophysis development]
GO:0030336 [negative regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030432 [peristalsis]
GO:0030672 [synaptic vesicle membrane]
GO:0030814 [regulation of cAMP metabolic process]
GO:0031513 [nonmotile primary cilium]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032467 [positive regulation of cytokinesis]
GO:0032922 [circadian regulation of gene expression]
GO:0034776 [response to histamine]
GO:0035240 [dopamine binding]
GO:0035556 [intracellular signal transduction]
GO:0042220 [response to cocaine]
GO:0042417 [dopamine metabolic process]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0043266 [regulation of potassium ion transport]
GO:0043278 [response to morphine]
GO:0045776 [negative regulation of blood pressure]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0048148 [behavioral response to cocaine]
GO:0048149 [behavioral response to ethanol]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048755 [branching morphogenesis of a nerve]
GO:0050482 [arachidonic acid secretion]
GO:0050709 [negative regulation of protein secretion]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0051586 [positive regulation of dopamine uptake involved in synaptic transmission]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0060124 [positive regulation of growth hormone secretion]
GO:0060134 [prepulse inhibition]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
GO:0060160 [negative regulation of dopamine receptor signaling pathway]
GO:0060170 [ciliary membrane]
GO:1900168 [positive regulation of glial cell-derived neurotrophic factor secretion]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
Show all
 445 aa
50.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.