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AASDHPPT

GENERAL INFORMATION

Gene name

 AASDHPPT

Gene description

 Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA026687
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AASDHPPT (HGNC Symbol)

Synonyms

 AASD-PPT, CGI-80, LYS5

Description

 Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q22.3

Chromosome location (bp)

 106075501 - 106098710

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149313 (version 83.38)

Entrez gene

 60496

UniProt

 Q9NRN7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRN7

Antibodypedia

 AASDHPPT antibodies

PROTEIN BROWSER
AASDHPPT-001
AASDHPPT-004
AASDHPPT-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AASDHPPT-001
ENSP00000278618
ENST00000278618
Q9NRN7 [Direct mapping]
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008897 [holo-[acyl-carrier-protein] synthase activity]
GO:0015939 [pantothenate metabolic process]
GO:0018070 [peptidyl-serine phosphopantetheinylation]
GO:0019878 [lysine biosynthetic process via aminoadipic acid]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 309 aa
35.8 kDa 		No 0
AASDHPPT-004
ENSP00000435099
ENST00000524411
E9PLW6 [Direct mapping]
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0006633 [fatty acid biosynthetic process]
GO:0008897 [holo-[acyl-carrier-protein] synthase activity]
Show all
 190 aa
22.2 kDa 		No 0
AASDHPPT-005
ENSP00000437175
ENST00000533423
E9PNF3 [Direct mapping]
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0006633 [fatty acid biosynthetic process]
GO:0008897 [holo-[acyl-carrier-protein] synthase activity]
Show all
 160 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.