Expression of GLB1L2 in cancer - Summary - The Human Protein Atlas

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GLB1L2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GLB1L2
Gene description	Galactosidase, beta 1-like 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, HaCaT, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in several cell types, most abundant in glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA054808 , HPA059955
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054808	HPA059955

GENE INFORMATION
Gene name	GLB1L2
Synonyms
Description	Galactosidase, beta 1-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q25
Chromosome location (bp)	134331874 - 134378341
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149328 (version 83.38)
Entrez gene	89944
UniProt	Q8IW92 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IW92
Antibodypedia	GLB1L2 antibodies

PROTEIN BROWSER

GLB1L2-002	GLB1L2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLB1L2-002 ENSP00000444628 ENST00000535456	Q8IW92 [Direct mapping] Beta-galactosidase-1-like protein 2 A0A024R3N9 [Target identity:100%; Query identity:100%] Beta-galactosidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004565 [beta-galactosidase activity] GO:0005576 [extracellular region] GO:0005975 [carbohydrate metabolic process] Show all	636 aa 72.1 kDa	Yes	0
GLB1L2-201 ENSP00000344659 ENST00000339772	Q8IW92 [Direct mapping] Beta-galactosidase-1-like protein 2 A0A024R3N9 [Target identity:100%; Query identity:100%] Beta-galactosidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004565 [beta-galactosidase activity] GO:0005576 [extracellular region] GO:0005975 [carbohydrate metabolic process] Show all	636 aa 72.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.