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LAMTOR1

GENERAL INFORMATION

Gene name

 LAMTOR1

Gene description

 Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA002997
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002997

GENE INFORMATION

Gene name

 LAMTOR1 (HGNC Symbol)

Synonyms

 C11orf59, FLJ20625, p18, p27RF-Rho, Pdro, Ragulator1

Description

 Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 72085895 - 72103387

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149357 (version 83.38)

Entrez gene

 55004

UniProt

 Q6IAA8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6IAA8

Antibodypedia

 LAMTOR1 antibodies

PROTEIN BROWSER
LAMTOR1-001
LAMTOR1-003
LAMTOR1-004
LAMTOR1-006
LAMTOR1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LAMTOR1-001
ENSP00000278671
ENST00000278671
Q6IAA8 [Direct mapping]
Ragulator complex protein LAMTOR1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001919 [regulation of receptor recycling]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007032 [endosome organization]
GO:0007040 [lysosome organization]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010872 [regulation of cholesterol esterification]
GO:0010874 [regulation of cholesterol efflux]
GO:0016049 [cell growth]
GO:0016236 [macroautophagy]
GO:0031902 [late endosome membrane]
GO:0032008 [positive regulation of TOR signaling]
GO:0032418 [lysosome localization]
GO:0032439 [endosome localization]
GO:0032947 [protein complex scaffold]
GO:0034613 [cellular protein localization]
GO:0042632 [cholesterol homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043547 [positive regulation of GTPase activity]
GO:0045121 [membrane raft]
GO:0060620 [regulation of cholesterol import]
GO:0070062 [extracellular exosome]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071986 [Ragulator complex]
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 161 aa
17.7 kDa 		No 0
LAMTOR1-003
ENSP00000438717
ENST00000544594
H0YFI1 [Direct mapping]
Ragulator complex protein LAMTOR1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001919 [regulation of receptor recycling]
GO:0007040 [lysosome organization]
GO:0031902 [late endosome membrane]
GO:0032008 [positive regulation of TOR signaling]
GO:0032439 [endosome localization]
GO:0042632 [cholesterol homeostasis]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045121 [membrane raft]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071986 [Ragulator complex]
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 79 aa
8.6 kDa 		No 0
LAMTOR1-004
ENSP00000439011
ENST00000538404
F5H3Y3 [Direct mapping]
Ragulator complex protein LAMTOR1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001919 [regulation of receptor recycling]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0007040 [lysosome organization]
GO:0031902 [late endosome membrane]
GO:0032008 [positive regulation of TOR signaling]
GO:0032439 [endosome localization]
GO:0042632 [cholesterol homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045121 [membrane raft]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071986 [Ragulator complex]
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 160 aa
17.5 kDa 		No 0
LAMTOR1-006
ENSP00000440738
ENST00000545249
F5GX19 [Direct mapping]
Ragulator complex protein LAMTOR1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001919 [regulation of receptor recycling]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0007040 [lysosome organization]
GO:0031902 [late endosome membrane]
GO:0032008 [positive regulation of TOR signaling]
GO:0032439 [endosome localization]
GO:0042632 [cholesterol homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045121 [membrane raft]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071986 [Ragulator complex]
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 142 aa
15.7 kDa 		No 0
LAMTOR1-008
ENSP00000445170
ENST00000535107
F5H479 [Direct mapping]
Ragulator complex protein LAMTOR1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001919 [regulation of receptor recycling]
GO:0007040 [lysosome organization]
GO:0031902 [late endosome membrane]
GO:0032008 [positive regulation of TOR signaling]
GO:0032439 [endosome localization]
GO:0042632 [cholesterol homeostasis]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045121 [membrane raft]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071986 [Ragulator complex]
Show all
 99 aa
11.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.