Cell atlas - ST14 - The Human Protein Atlas

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ST14

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ST14
Gene description	Suppression of tumorigenicity 14 (colon carcinoma)
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (CAPAN-2, T-47d, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047014
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, T-47d, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047014	CACO-2	Nucleoplasm
	HPA047014	CACO-2	Vesicles	Spatial
	HPA047014	HaCaT	No staining
	HPA047014	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	ST14 (HGNC Symbol)
Synonyms	HAI, MT-SP1, PRSS14, SNC19, TMPRSS14
Description	Suppression of tumorigenicity 14 (colon carcinoma) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q24.3
Chromosome location (bp)	130159562 - 130210376
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149418 (version 83.38)
Entrez gene	6768
UniProt	Q9Y5Y6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Y6
Antibodypedia	ST14 antibodies

PROTEIN BROWSER

ST14-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST14-001 ENSP00000278742 ENST00000278742	Q9Y5Y6 [Direct mapping] Suppressor of tumorigenicity 14 protein Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001843 [neural tube closure] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0019897 [extrinsic component of plasma membrane] GO:0030216 [keratinocyte differentiation] GO:0060672 [epithelial cell morphogenesis involved in placental branching] GO:0070062 [extracellular exosome] Show all	855 aa 94.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.