Expression of GGTLC1 in cancer - Summary - The Human Protein Atlas

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GGTLC1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GGTLC1
Gene description	Gamma-glutamyltransferase light chain 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (lung cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (lung, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA045635 , HPA047534
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (lung cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045635	HPA047534

GENE INFORMATION
Gene name	GGTLC1 (HGNC Symbol)
Synonyms	dJ831C21.1, dJ831C21.2, GGTLA3, GGTLA4
Description	Gamma-glutamyltransferase light chain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the gamma-glutamyl transpeptidase (GGT) family, which are important in the metabolism of glutathione. The most ubiquitously expressed human GGT gene, GGT1, encodes a single transmembrane polypeptide that is post-translationally processed to form a heavy and a light chain. In contrast, the product of this gene only contains homology to the light chain region, and lacks a transmembrane domain. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	23985050 - 23988779
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149435 (version 83.38)
Entrez gene	92086
UniProt	Q9BX51 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BX51
Antibodypedia	GGTLC1 antibodies

PROTEIN BROWSER

GGTLC1-001	GGTLC1-003	GGTLC1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGTLC1-001 ENSP00000278765 ENST00000278765	Q9BX51 [Direct mapping] Gamma-glutamyltransferase light chain 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] Show all	225 aa 24.3 kDa	No	0
GGTLC1-003 ENSP00000286890 ENST00000286890	Q9BX51 [Direct mapping] Gamma-glutamyltransferase light chain 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] Show all	225 aa 24.3 kDa	No	0
GGTLC1-006 ENSP00000337587 ENST00000335694	Q9BX51 [Direct mapping] Gamma-glutamyltransferase light chain 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] Show all	225 aa 24.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.