Expression of SLC22A8 in cancer - Summary - The Human Protein Atlas

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SLC22A8

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC22A8
Gene description	Solute carrier family 22 (organic anion transporter), member 8
Protein class	FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in proximal renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA044174
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044174

GENE INFORMATION
Gene name	SLC22A8 (HGNC Symbol)
Synonyms	OAT3
Description	Solute carrier family 22 (organic anion transporter), member 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62989154 - 63015839
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149452 (version 83.38)
Entrez gene	9376
UniProt	Q8TCC7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCC7
Antibodypedia	SLC22A8 antibodies

PROTEIN BROWSER

SLC22A8-001	SLC22A8-002	SLC22A8-003	SLC22A8-004	SLC22A8-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A8-001 ENSP00000337335 ENST00000336232	Q8TCC7 [Direct mapping] Solute carrier family 22 member 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0009636 [response to toxic substance] GO:0015075 [ion transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	542 aa 59.9 kDa	No	>9
SLC22A8-002 ENSP00000398548 ENST00000430500	Q8TCC7 [Direct mapping] Solute carrier family 22 member 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0009636 [response to toxic substance] GO:0015075 [ion transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	542 aa 59.9 kDa	No	>9
SLC22A8-003 ENSP00000441658 ENST00000545207	Q8TCC7 [Direct mapping] Solute carrier family 22 member 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0009636 [response to toxic substance] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	451 aa 49.8 kDa	No	>9
SLC22A8-004 ENSP00000311463 ENST00000311438	H7BXN9 [Direct mapping] Solute carrier family 22 (Organic anion transporter), member 8, isoform CRA_a; Solute carrier family 22 member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0015075 [ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	533 aa 58.7 kDa	No	>9
SLC22A8-008 ENSP00000443368 ENST00000535878	Q8TCC7 [Direct mapping] Solute carrier family 22 member 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0009636 [response to toxic substance] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098656 [anion transmembrane transport] Show all	419 aa 46.1 kDa	No	>9

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