Expression of CSRP2BP in cancer - Summary - The Human Protein Atlas

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CSRP2BP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CSRP2BP
Gene description	CSRP2 binding protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB034224
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB034224

GENE INFORMATION
Gene name	CSRP2BP (HGNC Symbol)
Synonyms	ATAC2, CRP2BP, dJ717M23.1, KAT14, PRO1194
Description	CSRP2 binding protein (HGNC Symbol)
Entrez gene summary	CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Chromosome	20
Cytoband	p11.23
Chromosome location (bp)	18138118 - 18188387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149474 (version 83.38)
Entrez gene	57325
UniProt	Q9H8E8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H8E8
Antibodypedia	CSRP2BP antibodies

PROTEIN BROWSER

CSRP2BP-001	CSRP2BP-002	CSRP2BP-005	CSRP2BP-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSRP2BP-001 ENSP00000392318 ENST00000435364	Q9H8E8 [Direct mapping] Cysteine-rich protein 2-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0004402 [histone acetyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0008080 [N-acetyltransferase activity] GO:0016573 [histone acetylation] GO:0030274 [LIM domain binding] GO:0043966 [histone H3 acetylation] Show all	782 aa 88.8 kDa	No	0
CSRP2BP-002 ENSP00000424752 ENST00000464792	D6RAU4 [Direct mapping] Cysteine-rich protein 2-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6 kDa	No	0
CSRP2BP-005 ENSP00000425909 ENST00000489634	Q9H8E8 [Direct mapping] Cysteine-rich protein 2-binding protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004402 [histone acetyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0008080 [N-acetyltransferase activity] GO:0030274 [LIM domain binding] GO:0043966 [histone H3 acetylation] Show all	654 aa 74.3 kDa	No	0
CSRP2BP-007 ENSP00000366909 ENST00000377681	A0A075B6H4 [Direct mapping] Cysteine-rich protein 2-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008080 [N-acetyltransferase activity] GO:0008152 [metabolic process] Show all	781 aa 88.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.