Expression of MS4A3 in cancer - Summary - The Human Protein Atlas

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MS4A3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MS4A3
Gene description	Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (HEL, K-562, NB-4, THP-1, U-937)
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in hematopoietic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA019210
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019210

GENE INFORMATION
Gene name	MS4A3 (HGNC Symbol)
Synonyms	CD20L, HTM4
Description	Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	60056587 - 60071128
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149516 (version 83.38)
Entrez gene	932
UniProt	Q96HJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HJ5
Antibodypedia	MS4A3 antibodies

PROTEIN BROWSER

MS4A3-001	MS4A3-002	MS4A3-003	MS4A3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MS4A3-001 ENSP00000278865 ENST00000278865	Q96HJ5 [Direct mapping] Membrane-spanning 4-domains subfamily A member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	214 aa 22.9 kDa	No	4
MS4A3-002 ENSP00000434117 ENST00000534744	Q96HJ5 [Direct mapping] Membrane-spanning 4-domains subfamily A member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	168 aa 17.6 kDa	No	2
MS4A3-003 ENSP00000378473 ENST00000395032	Q96HJ5 [Direct mapping] Membrane-spanning 4-domains subfamily A member 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	91 aa 9.6 kDa	Yes	0
MS4A3-201 ENSP00000350872 ENST00000358152	Q96HJ5 [Direct mapping] Membrane-spanning 4-domains subfamily A member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	168 aa 17.6 kDa	No	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.