Expression of MS4A2 in cancer - Summary - The Human Protein Atlas

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MS4A2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MS4A2
Gene description	Membrane-spanning 4-domains, subfamily A, member 2
Protein class	FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, THP-1)
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in a subset of lymphoid cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA059967
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059967

GENE INFORMATION
Gene name	MS4A2 (HGNC Symbol)
Synonyms	APY, FCER1B, IGER, MS4A1
Description	Membrane-spanning 4-domains, subfamily A, member 2 (HGNC Symbol)
Entrez gene summary	The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	60088261 - 60098466
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149534 (version 83.38)
Entrez gene	2206
UniProt	Q01362 (UniProt - Evidence at transcript level)
neXtProt	NX_Q01362
Antibodypedia	MS4A2 antibodies

PROTEIN BROWSER

MS4A2-001	MS4A2-003	MS4A2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MS4A2-001 ENSP00000278888 ENST00000278888	Q01362 [Direct mapping] High affinity immunoglobulin epsilon receptor subunit beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Biotech drugs Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0019863 [IgE binding] GO:0032998 [Fc-epsilon receptor I complex] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0045087 [innate immune response] Show all	244 aa 26.5 kDa	No	4
MS4A2-003 ENSP00000433311 ENST00000524868	E9PLJ1 [Direct mapping] High affinity immunoglobulin epsilon receptor subunit beta Show all	Predicted intracellular proteins Show all		41 aa 4.5 kDa	No	0
MS4A2-201 ENSP00000482594 ENST00000617306	A0A0B4J2E9 [Direct mapping] High affinity immunoglobulin epsilon receptor subunit beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	199 aa 21.6 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.