Cell atlas - SCN2B - The Human Protein Atlas

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SCN2B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SCN2B
Gene description	Sodium channel, voltage gated, type II beta subunit
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SCN2B
Synonyms
Description	Sodium channel, voltage gated, type II beta subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118161951 - 118176673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149575 (version 83.38)
Entrez gene	6327
UniProt	O60939 (UniProt - Evidence at protein level)
neXtProt	NX_O60939
Antibodypedia	SCN2B antibodies

PROTEIN BROWSER

SCN2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCN2B-001 ENSP00000278947 ENST00000278947	O60939 [Direct mapping] Sodium channel subunit beta-2 Q5U0K8 [Target identity:100%; Query identity:100%] Sodium channel, voltage-gated, type II, beta; cDNA, FLJ94526, Homo sapiens sodium channel, voltage-gated, type II, beta (SCN2B),mRNA Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0005248 [voltage-gated sodium channel activity] GO:0005515 [protein binding] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0017080 [sodium channel regulator activity] GO:0035725 [sodium ion transmembrane transport] GO:0046684 [response to pyrethroid] GO:0060048 [cardiac muscle contraction] GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization] GO:0086002 [cardiac muscle cell action potential involved in contraction] GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	215 aa 24.3 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.