Expression of TMEM25 in cancer - Summary - The Human Protein Atlas

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TMEM25

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM25
Gene description	Transmembrane protein 25
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (T-47d)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA012163
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012163

GENE INFORMATION
Gene name	TMEM25 (HGNC Symbol)
Synonyms	FLJ14399
Description	Transmembrane protein 25 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118531041 - 118547280
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149582 (version 83.38)
Entrez gene	84866
UniProt	Q86YD3 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YD3
Antibodypedia	TMEM25 antibodies

PROTEIN BROWSER

TMEM25-001	TMEM25-002	TMEM25-003	TMEM25-004	TMEM25-006	TMEM25-009	TMEM25-012	TMEM25-019	TMEM25-020	TMEM25-022	TMEM25-023	TMEM25-025	TMEM25-026	TMEM25-030	TMEM25-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM25-001 ENSP00000431548 ENST00000533102	E9PKP3 [Direct mapping] Transmembrane protein 25 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	381 aa 40.8 kDa	Yes	1
TMEM25-002 ENSP00000431205 ENST00000524725	Q86YD3 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	322 aa 34.8 kDa	Yes	0
TMEM25-003 ENSP00000278959 ENST00000354064	Q86YD3 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	218 aa 23.5 kDa	Yes	0
TMEM25-004 ENSP00000416071 ENST00000442938	Q86YD3 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	306 aa 33 kDa	Yes	0
TMEM25-006 ENSP00000411882 ENST00000411589	Q86YD3 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	322 aa 34.8 kDa	Yes	0
TMEM25-009 ENSP00000315635 ENST00000313236	Q86YD3 [Direct mapping] Transmembrane protein 25 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	366 aa 39.3 kDa	Yes	1
TMEM25-012 ENSP00000431145 ENST00000526853	H0YC87 [Direct mapping] Transmembrane protein 25 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	200 aa 21.5 kDa	No	1
TMEM25-019 ENSP00000433938 ENST00000533137	E9PIR4 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.1 kDa	Yes	0
TMEM25-020 ENSP00000433059 ENST00000526973	H0YD63 [Direct mapping] Transmembrane protein 25 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		195 aa 21.2 kDa	No	0
TMEM25-022 ENSP00000432040 ENST00000528373	E9PIE6 [Direct mapping] Transmembrane protein 25 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	167 aa 17.7 kDa	Yes	1
TMEM25-023 ENSP00000435446 ENST00000527267	E9PK88 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.2 kDa	Yes	0
TMEM25-025 ENSP00000436746 ENST00000533689	E9PI73 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	138 aa 14.7 kDa	Yes	0
TMEM25-026 ENSP00000433906 ENST00000532762	E9PIT4 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	168 aa 18.1 kDa	Yes	0
TMEM25-030 ENSP00000346237 ENST00000354284	Q86YD3 [Direct mapping] Transmembrane protein 25 A0A024R3G8 [Target identity:100%; Query identity:100%] Transmembrane protein 25, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	351 aa 37.6 kDa	Yes	1
TMEM25-201 ENSP00000352924 ENST00000359862	Q86YD3 [Direct mapping] Transmembrane protein 25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	322 aa 34.8 kDa	Yes	0

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The Human Protein Atlas

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