Expression of SOGA1 in cancer - Summary - The Human Protein Atlas

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SOGA1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SOGA1
Gene description	Suppressor of glucose, autophagy associated 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043992
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable) and renal cancer (unfavourable).
Ovarian cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043992

GENE INFORMATION
Gene name	SOGA1 (HGNC Symbol)
Synonyms	C20orf117, dJ132F21.1, FLJ44670, KIAA0889, SOGA
Description	Suppressor of glucose, autophagy associated 1 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	36777442 - 36863686
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149639 (version 83.38)
Entrez gene	140710
UniProt	O94964 (UniProt - Evidence at protein level)
neXtProt	NX_O94964
Antibodypedia	SOGA1 antibodies

PROTEIN BROWSER

SOGA1-003	SOGA1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SOGA1-003 ENSP00000279034 ENST00000279034	X6R3R3 [Direct mapping] Protein SOGA1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0008286 [insulin receptor signaling pathway] GO:0010506 [regulation of autophagy] Show all	1016 aa 115.8 kDa	No	0
SOGA1-005 ENSP00000237536 ENST00000237536	O94964 [Direct mapping] Protein SOGA1 N-terminal form C-terminal 80 kDa form Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005615 [extracellular space] GO:0008286 [insulin receptor signaling pathway] GO:0010506 [regulation of autophagy] GO:0045721 [negative regulation of gluconeogenesis] GO:0070062 [extracellular exosome] Show all	1661 aa 183.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.