Expression of LSM14B in cancer - Summary - The Human Protein Atlas

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LSM14B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LSM14B
Gene description	LSM family member 14B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, mainly in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA041274 , HPA061189
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041274	HPA061189

GENE INFORMATION
Gene name	LSM14B (HGNC Symbol)
Synonyms	bA11M20.3, C20orf40, FAM61B, FLJ25473, FT005, LSM13, RAP55B
Description	LSM family member 14B (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	62122461 - 62135378
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149657 (version 83.38)
Entrez gene	149986
UniProt	Q9BX40 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BX40
Antibodypedia	LSM14B antibodies

PROTEIN BROWSER

LSM14B-001	LSM14B-002	LSM14B-003	LSM14B-005	LSM14B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSM14B-001 ENSP00000279068 ENST00000279068	Q9BX40 [Direct mapping] Protein LSM14 homolog B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006417 [regulation of translation] GO:0007275 [multicellular organismal development] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	385 aa 42.1 kDa	No	0
LSM14B-002 ENSP00000279069 ENST00000279069	Q5TBQ1 [Direct mapping] Protein LSM14 homolog B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		223 aa 23.8 kDa	No	0
LSM14B-003 ENSP00000383172 ENST00000400318	Q5TBQ0 [Direct mapping] Protein LSM14 homolog B Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		296 aa 32.1 kDa	No	0
LSM14B-005 ENSP00000359953 ENST00000370915	A0A0C4DFV2 [Direct mapping] Protein LSM14 homolog B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		221 aa 23.3 kDa	No	0
LSM14B-006 ENSP00000355209 ENST00000361670	Q5TBP9 [Direct mapping] Protein LSM14 homolog B Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		248 aa 26.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.