Expression of GPHA2 in cancer - Summary - The Human Protein Atlas

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GPHA2

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	GPHA2
Gene description	Glycoprotein hormone alpha 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Group enriched (gallbladder, pancreas)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	GPHA2 (HGNC Symbol)
Synonyms	A2, GPA2, MGC126572, ZSIG51
Description	Glycoprotein hormone alpha 2 (HGNC Symbol)
Entrez gene summary	GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64934471 - 64935888
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149735 (version 83.38)
Entrez gene	170589
UniProt	Q96T91 (UniProt - Evidence at protein level)
neXtProt	NX_Q96T91
Antibodypedia	GPHA2 antibodies

PROTEIN BROWSER

GPHA2-001	GPHA2-002	GPHA2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPHA2-001 ENSP00000279168 ENST00000279168	Q96T91 [Direct mapping] Glycoprotein hormone alpha-2 A0A024R579 [Target identity:100%; Query identity:100%] Glycoprotein hormone alpha 2, isoform CRA_a; Glycoprotein-alpha 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	129 aa 14.2 kDa	Yes	0
GPHA2-002 ENSP00000432918 ENST00000533257	Q96T91 [Direct mapping] Glycoprotein hormone alpha-2 A0A024R579 [Target identity:100%; Query identity:100%] Glycoprotein hormone alpha 2, isoform CRA_a; Glycoprotein-alpha 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	129 aa 14.2 kDa	Yes	0
GPHA2-003 ENSP00000431352 ENST00000532246	E9PLQ0 [Direct mapping] Glycoprotein hormone alpha-2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		118 aa 12.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.