Expression of MRPL49 in cancer - Summary - The Human Protein Atlas

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MRPL49

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPL49
Gene description	Mitochondrial ribosomal protein L49
Protein class	Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA046778
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046778

GENE INFORMATION
Gene name	MRPL49 (HGNC Symbol)
Synonyms	C11orf4, L49mt, NOF, NOF1
Description	Mitochondrial ribosomal protein L49 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65122183 - 65127371
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149792 (version 83.38)
Entrez gene	740
UniProt	Q13405 (UniProt - Evidence at protein level)
neXtProt	NX_Q13405
Antibodypedia	MRPL49 antibodies

PROTEIN BROWSER

MRPL49-001	MRPL49-005	MRPL49-006	MRPL49-008	MRPL49-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL49-001 ENSP00000279242 ENST00000279242	Q13405 [Direct mapping] 39S ribosomal protein L49, mitochondrial A0A024R578 [Target identity:100%; Query identity:100%] Mitochondrial ribosomal protein L49, isoform CRA_b Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	166 aa 19.2 kDa	No	0
MRPL49-005 ENSP00000434052 ENST00000533943	H0YDP7 [Direct mapping] 39S ribosomal protein L49, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] Show all	127 aa 14.6 kDa	No	0
MRPL49-006 ENSP00000437177 ENST00000526171	E9PNF1 [Direct mapping] 39S ribosomal protein L49, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] Show all	140 aa 16 kDa	No	0
MRPL49-008 ENSP00000434222 ENST00000534078	E9PRD2 [Direct mapping] 39S ribosomal protein L49, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005762 [mitochondrial large ribosomal subunit] Show all	56 aa 6.1 kDa	No	0
MRPL49-009 ENSP00000436740 ENST00000531705	E9PI78 [Direct mapping] 39S ribosomal protein L49, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] Show all	99 aa 11.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.