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DOC2A

GENERAL INFORMATION

Gene name

 DOC2A

Gene description

 Double C2-like domains, alpha

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Cell line enhanced (SCLC-21H, U-937)
HPA (normal tissue):Group enriched (cerebral cortex, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DOC2A

Synonyms

Description

 Double C2-like domains, alpha (HGNC Symbol)

Entrez gene summary

 There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 30005509 - 30023270

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149927 (version 83.38)

Entrez gene

 8448

UniProt

 Q14183 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14183

Antibodypedia

 DOC2A antibodies

PROTEIN BROWSER
DOC2A-001
DOC2A-005
DOC2A-006
DOC2A-008
DOC2A-009
DOC2A-012
DOC2A-013
DOC2A-019
DOC2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DOC2A-001
ENSP00000340017
ENST00000350119
Q14183 [Direct mapping]
Double C2-like domain-containing protein alpha
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0043005 [neuron projection]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 400 aa
44 kDa 		No 0
DOC2A-005
ENSP00000455196
ENST00000564944
Q14183 [Direct mapping]
Double C2-like domain-containing protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0043005 [neuron projection]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 400 aa
44 kDa 		No 0
DOC2A-006
ENSP00000455624
ENST00000564979
Q14183 [Direct mapping]
Double C2-like domain-containing protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0043005 [neuron projection]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 400 aa
44 kDa 		No 0
DOC2A-008
ENSP00000454827
ENST00000567332
H3BNF7 [Direct mapping]
Double C2-like domain-containing protein alpha
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Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 80 aa
9.1 kDa 		No 0
DOC2A-009
ENSP00000456704
ENST00000563378
H3BSH4 [Direct mapping]
Double C2-like domain-containing protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 204 aa
22.1 kDa 		No 0
DOC2A-012
ENSP00000457454
ENST00000563125
H3BU41 [Direct mapping]
Double C2-like domain-containing protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 53 aa
6 kDa 		No 0
DOC2A-013
ENSP00000457184
ENST00000565273
H3BTI1 [Direct mapping]
Double C2-like domain-containing protein alpha
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Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 218 aa
23.9 kDa 		No 0
DOC2A-019
ENSP00000460622
ENST00000574405
I3L3P9 [Direct mapping]
Double C2-like domain-containing protein alpha
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Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 13 aa
1.5 kDa 		No 0
DOC2A-201
ENSP00000482870
ENST00000616445
Q14183 [Direct mapping]
Double C2-like domain-containing protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0043005 [neuron projection]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 400 aa
44 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.