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TAOK2

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GENERAL INFORMATION

Gene name

 TAOK2

Gene description

 TAO kinase 2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & cytosol. In addition localized to the nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Cytosol (approved)

Additional location

 In addition localized to the Nucleoli (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA010650
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & cytosol. In addition localized to the nucleoli.

Main location

 Nucleus (supported), Cytosol (approved)

Additional location

 Nucleoli (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA010650 A-431 Nucleus
Cytosol
HPA010650 U-2 OS Nucleus
Cytosol
HPA010650 U-251 MG Nucleus
Nucleoli
Cytosol

GENE INFORMATION

Gene name

 TAOK2 (HGNC Symbol)

Synonyms

 KIAA0881, MAP3K17, PSK, PSK1, TAO1, TAO2

Description

 TAO kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 29973641 - 29992261

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149930 (version 83.38)

Entrez gene

 9344

UniProt

 Q9UL54 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UL54

Antibodypedia

 TAOK2 antibodies

PROTEIN BROWSER
TAOK2-001
TAOK2-002
TAOK2-003
TAOK2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAOK2-001
ENSP00000279394
ENST00000279394
Q9UL54 [Direct mapping]
Serine/threonine-protein kinase TAO2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0006612 [protein targeting to membrane]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0030425 [dendrite]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031572 [G2 DNA damage checkpoint]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0046330 [positive regulation of JNK cascade]
GO:0048041 [focal adhesion assembly]
GO:0051403 [stress-activated MAPK cascade]
Show all
 1049 aa
119.3 kDa 		No 0
TAOK2-002
ENSP00000310094
ENST00000308893
Q9UL54 [Direct mapping]
Serine/threonine-protein kinase TAO2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0006612 [protein targeting to membrane]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0030425 [dendrite]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031572 [G2 DNA damage checkpoint]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0046330 [positive regulation of JNK cascade]
GO:0048041 [focal adhesion assembly]
GO:0051403 [stress-activated MAPK cascade]
Show all
 1235 aa
138.3 kDa 		No 4
TAOK2-003
ENSP00000440336
ENST00000543033
Q9UL54 [Direct mapping]
Serine/threonine-protein kinase TAO2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0006612 [protein targeting to membrane]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0030425 [dendrite]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031572 [G2 DNA damage checkpoint]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0046330 [positive regulation of JNK cascade]
GO:0048041 [focal adhesion assembly]
GO:0051403 [stress-activated MAPK cascade]
Show all
 1122 aa
126.2 kDa 		No 4
TAOK2-004
ENSP00000393048
ENST00000416441
Q9UL54 [Direct mapping]
Serine/threonine-protein kinase TAO2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006612 [protein targeting to membrane]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0030425 [dendrite]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031572 [G2 DNA damage checkpoint]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0046330 [positive regulation of JNK cascade]
GO:0048041 [focal adhesion assembly]
GO:0051403 [stress-activated MAPK cascade]
Show all
 1062 aa
118.8 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.