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MKX

GENERAL INFORMATION

Gene name

 MKX

Gene description

 Mohawk homeobox

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (ovary, prostate)
GTEx:Tissue enhanced (prostate)
FANTOM5:Tissue enhanced (ovary, pituitary gland, prostate)

Protein evidence

 Evidence at transcript level

Protein expression

 Expression in several different tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA006927
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Nasopharynx

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary, pituitary gland, prostate)

GENE INFORMATION

Gene name

 MKX (HGNC Symbol)

Synonyms

 C10orf48, IRXL1, MGC39616

Description

 Mohawk homeobox (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 27672875 - 27746060

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000150051 (version 83.38)

Entrez gene

 283078

UniProt

 Q8IYA7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8IYA7

Antibodypedia

 MKX antibodies

PROTEIN BROWSER
MKX-001
MKX-002
MKX-003
MKX-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MKX-001
ENSP00000364946
ENST00000375790
Q8IYA7 [Direct mapping]
Homeobox protein Mohawk
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0002932 [tendon sheath development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0030199 [collagen fibril organization]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0035990 [tendon cell differentiation]
GO:0035992 [tendon formation]
GO:0043565 [sequence-specific DNA binding]
GO:0045662 [negative regulation of myoblast differentiation]
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 352 aa
39.3 kDa 		No 0
MKX-002
ENSP00000452751
ENST00000460919
H0YKC7 [Direct mapping]
Homeobox protein Mohawk
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 290 aa
32.6 kDa 		No 0
MKX-003
ENSP00000453746
ENST00000561227
H0YMU2 [Direct mapping]
Homeobox protein Mohawk
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Predicted intracellular proteins
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 58 aa
6.2 kDa 		No 0
MKX-201
ENSP00000400896
ENST00000419761
Q8IYA7 [Direct mapping]
Homeobox protein Mohawk
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0043565 [sequence-specific DNA binding]
Show all
 352 aa
39.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.